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Study · Animal study (in vivo) · rat (wistar) · 2022

4 results

POSSIBLE ROLE OF KISSPEPTIN IN TESTOSTERONE-INDEPENDENT REGULATION OF SEXUAL MOTIVATION IN MALE RATS.

Tissen I, Magarramova L, Badrutdinov R, Takeeva Z, Proshin S, Shabanov P

Georgian medical news1 Feb 2022

PMID35271483 (opens in a new tab)PepBankPUB-35271483
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intraperitoneal kisspeptin‑10 affected testosterone concentration; the abstract does not give the direction.

    In plain wordsIn male rats, kisspeptin‑10 given into the abdomen changed testosterone levels; the abstract does not say whether up or down.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedTestosterone concentration after intraperitoneal kisspeptin-10
    Study

    rat (Wistar)n: not reported in source

    copulation-naive male rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    30 ng · intraperitonealAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Intraperitoneal administration of Kisspeptin-10 affect both of testosterone concentration and sexual motivation.
    1 context sentence
    Summary · context
    In this study 50 copulation naive male Wistar rats divided into 5 groups received saline, buserelin acetate (GnRH analogue) (20 μg), kisspeptin-10 (3 ng) intranasally, kisspeptin-10 (30 ng) intraperitoneally and Yoquimbine 200 µg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intraperitoneal kisspeptin‑10 affected sexual motivation; the abstract does not give the direction.

    In plain wordsIn male rats, kisspeptin‑10 given into the abdomen changed sexual motivation; the abstract does not say whether up or down.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedSexual motivation after intraperitoneal kisspeptin-10
    Study

    rat (Wistar)n: not reported in source

    copulation-naive male rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    30 ng · intraperitonealAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Intraperitoneal administration of Kisspeptin-10 affect both of testosterone concentration and sexual motivation.
    1 context sentence
    Summary · context
    In this study 50 copulation naive male Wistar rats divided into 5 groups received saline, buserelin acetate (GnRH analogue) (20 μg), kisspeptin-10 (3 ng) intranasally, kisspeptin-10 (30 ng) intraperitoneally and Yoquimbine 200 µg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intranasal kisspeptin‑10 did not change testosterone concentration.

    In plain wordsIn male rats, kisspeptin‑10 given in the nose did not change testosterone levels.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTestosterone concentration after intranasal kisspeptin-10
    Study

    rat (Wistar)n: not reported in source

    copulation-naive male rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3 ng · intranasalAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Intranasal administration of kisspeptin-10 didn't act testosterone
    1 context sentence
    Summary · context
    In this study 50 copulation naive male Wistar rats divided into 5 groups received saline, buserelin acetate (GnRH analogue) (20 μg), kisspeptin-10 (3 ng) intranasally, kisspeptin-10 (30 ng) intraperitoneally and Yoquimbine 200 µg.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intranasal kisspeptin‑10 increased sexual motivation.

    In plain wordsIn male rats, kisspeptin‑10 given in the nose increased sexual motivation compared with saline.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSexual motivation after intranasal kisspeptin-10
    Study

    rat (Wistar)n: not reported in source

    copulation-naive male rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    3 ng · intranasalAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Intranasal administration of kisspeptin-10 didn't act testosterone but increased sexual motivation.
    1 context sentence
    Summary · context
    In this study 50 copulation naive male Wistar rats divided into 5 groups received saline, buserelin acetate (GnRH analogue) (20 μg), kisspeptin-10 (3 ng) intranasally, kisspeptin-10 (30 ng) intraperitoneally and Yoquimbine 200 µg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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