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Study · Animal study (in vivo) · mouse · 2022

6 results

Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release.

Tsuji T, Furuhara K, Gerasimenko M, Shabalova A, Cherepanov SM, Minami K, Higashida H, Tsuji C

Nutrients14 Feb 2022Cited by 13 (Europe PMC)

PMID35215455 (opens in a new tab)PMCIDPMC8879915 (opens in a new tab)DOI10.3390/nu14040803 (opens in a new tab)PepBankPUB-35215455
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Summary

The outcomes of supplementation with L-carnosine have been investigated in clinical trials in children with autism spectrum disorder (ASD). However, reports on the effects of L-carnosine in humans have been inconsistent, and the efficacy of L-carnosine supplementation for improving ASD symptoms has yet to be investigated in animal studies. Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD. Social deficits in CD157KO mice were assessed using a three-chamber social approach test. Oral supplementation with L-carnosine attenuated social behavioral deficits. The number of c-Fos-positive oxytocin neurons in the supraoptic nucleus and paraventricular nucleus was increased with L-carnosine supplementation in CD157KO mice after the three-chamber social approach test. We observed an increase in the number of c-Fos-positive neurons in the basolateral amygdala, a brain region involved in social behavior. Although the expression of oxytocin and oxytocin receptors in the hypothalamus was not altered by L-carnosine supplementation, the concentration of oxytocin in cerebrospinal fluid was increased in CD157KO mice by L-carnosine supplementation. These results suggest that L-carnosine supplementation restores social recognition impairments by augmenting the level of released oxytocin. Thus, we could imply the possibility of a safe nutritional intervention for at least some types of ASD in the human population.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In CD157KO mice, oral L‑carnosine attenuated social behavioral deficits.

    In plain wordsIn mice lacking CD157, oral L‑carnosine reduced social behavioral deficits.

    Peptide
    L-carnosine
    Outcome
    DecreaseSocial behavioral deficits
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    Oral supplementation with L-carnosine attenuated social behavioral deficits.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In CD157KO mice, L‑carnosine increased c-Fos-positive oxytocin neurons in the supraoptic and paraventricular nuclei after social testing.

    In plain wordsIn mice lacking CD157, L‑carnosine increased activated oxytocin neurons after social testing.

    Peptide
    L-carnosine
    Outcome
    Increasec-Fos-positive oxytocin neurons
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    The number of c-Fos-positive oxytocin neurons in the supraoptic nucleus and paraventricular nucleus was increased with L-carnosine supplementation in CD157KO mice after the three-chamber social approach test.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In CD157KO mice, L‑carnosine increased c-Fos-positive neurons in the basolateral amygdala.

    In plain wordsIn mice lacking CD157, L‑carnosine increased activated neurons in the basolateral amygdala.

    Peptide
    L-carnosine
    Outcome
    IncreaseBasolateral amygdala c-Fos-positive neurons
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    We observed an increase in the number of c-Fos-positive neurons in the basolateral amygdala, a brain region involved in social behavior.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In CD157KO mice, L‑carnosine did not alter hypothalamic oxytocin expression.

    In plain wordsIn mice lacking CD157, L‑carnosine did not alter hypothalamic oxytocin expression.

    Peptide
    L-carnosine
    Outcome
    No significant changeHypothalamic oxytocin expression
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    Although the expression of oxytocin and oxytocin receptors in the hypothalamus was not altered by L-carnosine supplementation, the concentration of oxytocin in cerebrospinal fluid was increased in CD157KO mice by L-carnosine supplementation.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In CD157KO mice, L‑carnosine did not alter hypothalamic oxytocin receptor expression.

    In plain wordsIn mice lacking CD157, L‑carnosine did not alter hypothalamic oxytocin receptor expression.

    Peptide
    L-carnosine
    Outcome
    No significant changeHypothalamic oxytocin receptor expression
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    Although the expression of oxytocin and oxytocin receptors in the hypothalamus was not altered by L-carnosine supplementation, the concentration of oxytocin in cerebrospinal fluid was increased in CD157KO mice by L-carnosine supplementation.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In CD157KO mice, L‑carnosine increased cerebrospinal fluid oxytocin concentration.

    In plain wordsIn mice lacking CD157, L‑carnosine increased oxytocin concentration in cerebrospinal fluid.

    Peptide
    L-carnosine
    Outcome
    IncreaseCSF oxytocin concentration
    Study

    mousen: not reported in source

    CD157KO mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    Although the expression of oxytocin and oxytocin receptors in the hypothalamus was not altered by L-carnosine supplementation, the concentration of oxytocin in cerebrospinal fluid was increased in CD157KO mice by L-carnosine supplementation.
    2 context sentences
    Summary · context
    Here, we examined the effects of oral supplementation with L-carnosine on social deficits in CD157KO mice, a murine model of ASD.
    Summary · context
    Social deficits in CD157KO mice were assessed using a three-chamber social approach test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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