The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.

Liu X, Dilxat T, Shi Q, Qiu T, Lin J

Gene17 Feb 2022Cited by 28 (Europe PMC)

PMID35183682DOI10.1016/j.gene.2022.146348PepBankPUB-35183682

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study23

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone23

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

01AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aging rats, NMN plus lycopene improved spatial location learning.
In plain wordsIn rats with induced aging, NMN plus lycopene improved spatial learning.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSpatial learning
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Morris water maze test showed that NMN + Lyco effectively improved the ability of spatial location learning and memory of aging model rats.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368201
02AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aging rats, NMN plus lycopene improved memory.
In plain wordsIn rats with induced aging, NMN plus lycopene improved memory.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMemory
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Morris water maze test showed that NMN + Lyco effectively improved the ability of spatial location learning and memory of aging model rats.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368202
03AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene elevated SOD levels.
In plain wordsIn rats with induced aging, NMN plus lycopene increased brain and liver SOD levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSOD levels
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368203
04AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene elevated CAT levels.
In plain wordsIn rats with induced aging, NMN plus lycopene increased brain and liver CAT levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCAT levels
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368204
05AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene elevated GSH-Px levels.
In plain wordsIn rats with induced aging, NMN plus lycopene increased brain and liver GSH-Px levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGSH-Px levels
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368205
06AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene elevated GSH levels.
In plain wordsIn rats with induced aging, NMN plus lycopene increased brain and liver GSH levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGSH levels
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368206
07AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene elevated total antioxidant capacity.
In plain wordsIn rats with induced aging, NMN plus lycopene increased brain and liver antioxidant capacity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseTotal antioxidant capacity
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368207
08AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rat brains and livers, NMN plus lycopene reduced MDA content.
In plain wordsIn rats with induced aging, NMN plus lycopene reduced brain and liver MDA content.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMDA content
Study
ratn: not reported in source
Brain and liver in D-galactose-induced aging
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368208
09AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rats, NMN plus lycopene reduced p53 expression.
In plain wordsIn rats, NMN plus lycopene reduced p53 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep53 expression
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368216
10AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rats, NMN plus lycopene reduced p21 expression.
In plain wordsIn rats, NMN plus lycopene reduced p21 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep21 expression
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368217
11AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rats, NMN plus lycopene reduced p16 expression.
In plain wordsIn rats, NMN plus lycopene reduced p16 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep16 expression
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368218
12AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aging rats, NMN plus lycopene activated Keap1-Nrf2 signaling.
In plain wordsIn rats, NMN plus lycopene activated Keap1-Nrf2 signaling.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseKeap1-Nrf2 signaling
Study
ratn: not reported in source
D-galactose-induced aging
Outcome group
Receptor activity and mechanism · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368219
13LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene elevated SOD levels.
In plain wordsIn cells, NMN plus lycopene increased SOD levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSOD levels
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368209
14LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene elevated CAT levels.
In plain wordsIn cells, NMN plus lycopene increased CAT levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCAT levels
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368210
15LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene elevated GSH-Px levels.
In plain wordsIn cells, NMN plus lycopene increased GSH-Px levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGSH-Px levels
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368211
16LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene elevated GSH levels.
In plain wordsIn cells, NMN plus lycopene increased GSH levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGSH levels
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368212
17LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene elevated total antioxidant capacity.
In plain wordsIn cells, NMN plus lycopene increased total antioxidant capacity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseTotal antioxidant capacity
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368213
18LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene reduced MDA content.
In plain wordsIn cells, NMN plus lycopene reduced MDA content.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMDA content
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368214
19LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In D-galactose-treated PC12 cells, NMN plus lycopene reduced cellular senescence.
In plain wordsIn cells, NMN plus lycopene reduced induced cellular aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCellular senescence
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Aging markers · Whole body
Source sentences
Summary
CCK-8 assay, senescence-associated β-galactosidase staining, and flow cytometer confirmed the cellular senescence of PC12 cells after exposing D-gal, and indicated the anti-senescence effect of NMN + Lyco in vitro.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368215
20LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene reduced p53 expression.
In plain wordsIn cells, NMN plus lycopene reduced p53 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep53 expression
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368220
21LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene reduced p21 expression.
In plain wordsIn cells, NMN plus lycopene reduced p21 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep21 expression
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368221
22LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene reduced p16 expression.
In plain wordsIn cells, NMN plus lycopene reduced p16 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep16 expression
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Aging markers · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368222
23LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In senescent PC12 cells, NMN plus lycopene activated Keap1-Nrf2 signaling.
In plain wordsIn cells, NMN plus lycopene activated Keap1-Nrf2 signaling.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseKeap1-Nrf2 signaling
Study
n: not reported in source
D-galactose-treated PC12 cells
Outcome group
Receptor activity and mechanism · Whole body
Source sentences
Summary
Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells.
Summary · context
Both in vivo and in vitro aging models were established using D-galactose (D-gal).
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3518368223

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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