Hypomethylation of thymosin β4 promoter is associated with glucocorticoid therapy in patients with acute-on-chronic hepatitis B-induced liver failure.

Wang H, Qian Y, Wang JW, Fang Y, Fan YC, Liu HH, Wang K

International health1 Jan 2023Cited by 4 (Europe PMC)

PMID35150577PMCIDPMC9808517DOI10.1093/inthealth/ihac003PepBankPUB-35150577

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with acute-on-chronic hepatitis B liver failure, the body's own Tβ4 mRNA expression was lower than in patients with chronic hepatitis B or healthy controls.
In plain wordsIn people with this liver failure, the body's own Tβ4 mRNA levels were lower than in people with chronic hepatitis B or healthy people.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTβ4 mRNA expression in ACHBLF versus CHB and healthy controls
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Tβ4 mRNA expression of patients with ACHBLF was lower than in patients with CHB or HCs
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057701
02HumanEndogenous levelObservational studyOther
In patients with acute-on-chronic hepatitis B liver failure, the methylation frequency of the Tβ4 promoter was higher than in patients with chronic hepatitis B or healthy controls.
In plain wordsIn people with this liver failure, the gene for the body's own Tβ4 was more often methylated than in the other groups.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 promoter methylation frequency in ACHBLF
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
but the methylation frequency was higher.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057702
03HumanEndogenous levelObservational studyOther
In patients with acute-on-chronic hepatitis B liver failure, Tβ4 promoter methylation frequency correlated with serum total bilirubin, prothrombin activity and MELD score.
In plain wordsIn this liver failure, more methylation of the gene for the body's own Tβ4 was linked to worse liver tests and severity.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of Tβ4 promoter methylation with bilirubin, prothrombin activity and MELD score
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Tβ4 promoter methylation frequency was correlated with serum total bilirubin, prothrombin activity and model for end-stage liver disease score.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057703
04HumanEndogenous levelObservational studyOther
In patients with acute-on-chronic hepatitis B liver failure, Tβ4 promoter methylation frequency decreased during glucocorticoid therapy.
In plain wordsIn people with this liver failure, methylation of the gene for the body's own Tβ4 fell during glucocorticoid treatment.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTβ4 promoter methylation frequency during glucocorticoid therapy
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Moreover, Tβ4 promoter methylation frequency decreased and demethylation occurred during glucocorticoid therapy.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057704
05HumanEndogenous levelObservational studyOther
After glucocorticoid therapy, Tβ4 mRNA expression was better in patients with low methylation levels than in those with higher levels.
In plain wordsAfter glucocorticoid treatment, the body's own Tβ4 mRNA levels were better in people with low methylation than in people with high methylation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 mRNA expression after glucocorticoid therapy by methylation level
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
After glucocorticoid therapy, Tβ4 mRNA expression
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057705
06HumanEndogenous levelObservational studyOther
After glucocorticoid therapy, liver function was better in patients with low Tβ4 methylation levels than in those with higher levels.
In plain wordsAfter glucocorticoid treatment, liver function was better with low methylation of the gene for the body's own Tβ4 than with high.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseLiver function after glucocorticoid therapy by methylation level
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
After glucocorticoid therapy, Tβ4 mRNA expression and liver function were better in patients with low levels of methylation than in those with higher levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057706
07HumanEndogenous levelObservational studyOther
At 90 days, survival was significantly higher in patients with low Tβ4 methylation levels than in those with high levels.
In plain wordsAt 90 days, more people with low methylation of the gene for the body's own Tβ4 were alive than people with high methylation.
Peptide
Thymosin beta-4 (human)
Outcome
Increase90-day survival by Tβ4 methylation level
Study
n: not reported in source
Outcome group
Mortality · Liver
Source sentences
Summary
After 90 d, the survival of patients with low levels of methylation was significantly higher than those with high levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-six patients with ACHBLF, 45 with chronic hepatitis B (CHB) and 32 healthy controls (HCs), were retrospectively enrolled.
Summary · context
Methylation-specific PCR and real-time PCR were used to detect Tβ4 methylation frequency and mRNA level.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3515057707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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