Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin.

Hegazy MA, Abdelmonsif DA, Zeitoun TM, El-Sayed NS, Samy DM

Journal of physiology and biochemistry29 Jan 2022Cited by 29 (Europe PMC)

PMID35091983DOI10.1007/s13105-021-00845-6PepBankPUB-35091983

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In STZ-injected rats, carnosine almost normalized hippocampal FNDC5/irisin expression.
In plain wordsIn rats given STZ, carnosine almost restored hippocampal FNDC5/irisin expression compared with vehicle.
Peptide
L-carnosine
Outcome
IncreaseHippocampal FNDC5/irisin expression
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198301
02AnimalAnimal study (in vivo)Mechanism
In STZ-injected rats, carnosine intake was associated with reduced soluble β-amyloid peptide.
In plain wordsIn rats given STZ, carnosine was associated with less soluble β-amyloid peptide compared with vehicle.
Peptide
L-carnosine
Outcome
DecreaseSoluble β-amyloid peptide
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198302
03AnimalAnimal study (in vivo)Mechanism
In STZ-injected rats, carnosine intake was associated with reduced phosphorylated tau protein.
In plain wordsIn rats given STZ, carnosine was associated with less phosphorylated tau protein compared with vehicle.
Peptide
L-carnosine
Outcome
DecreasePhosphorylated tau protein
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198303
04AnimalAnimal study (in vivo)Mechanism
In STZ-injected rats, carnosine intake was associated with improved BDNF.
In plain wordsIn rats given STZ, carnosine was associated with improved BDNF compared with vehicle.
Peptide
L-carnosine
Outcome
Direction not reportedBDNF
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198304
05AnimalAnimal study (in vivo)Mechanism
In STZ-injected rats, carnosine intake was associated with improved insulin signalling proteins.
In plain wordsIn rats given STZ, carnosine was associated with improved insulin signalling proteins compared with vehicle.
Peptide
L-carnosine
Outcome
Direction not reportedInsulin signalling proteins
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198305
06AnimalAnimal study (in vivo)Efficacy outcome
In STZ-injected rats, carnosine intake mitigated cognitive impairments.
In plain wordsIn rats given STZ, carnosine reduced cognitive impairment compared with vehicle.
Peptide
L-carnosine
Outcome
DecreaseCognitive impairment
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198306
07AnimalAnimal study (in vivo)Efficacy outcome
In STZ-injected rats, carnosine ameliorated hippocampal damage on histology.
In plain wordsIn rats given STZ, carnosine reduced hippocampal damage compared with vehicle.
Peptide
L-carnosine
Outcome
DecreaseHippocampal damage
Study
ratn: not reported in source
ICV-STZ-injected rats
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 mg/kg/day · oral · 5 weeksAs given in this study (rat).
Source sentences
Summary
Histologically, both interventions ameliorated the hippocampal damage in STZ-injected rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ.
Summary · context
Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated.
Summary · context
After 5 weeks, rats were sacrificed after neurobehavioural testing.
Report a problemFND-3509198307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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