Skip to content

Study · Animal study (in vivo) · rat · 2022

7 results

Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.

El Kattawy HA, Abozaid ER, Abdullah DM

Current molecular pharmacology1 Jan 2022Cited by 8 (Europe PMC)

PMID35086467 (opens in a new tab)DOI10.2174/1874467215666220127115602 (opens in a new tab)PepBankPUB-35086467
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin treatment significantly improved serum testosterone.

    In plain wordsIn aged male rats with low testosterone, humanin treatment improved serum testosterone.

    Peptide
    Humanin
    Outcome
    IncreaseSerum testosterone
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin treatment significantly improved serum testosterone, sperm characteristics, and antioxidant defenses.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin treatment significantly improved sperm characteristics.

    In plain wordsIn aged male rats with low testosterone, humanin treatment improved sperm characteristics.

    Peptide
    Humanin
    Outcome
    IncreaseSperm characteristics
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin treatment significantly improved serum testosterone, sperm characteristics, and antioxidant defenses.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin treatment significantly improved antioxidant defenses.

    In plain wordsIn aged male rats with low testosterone, humanin treatment improved antioxidant defenses.

    Peptide
    Humanin
    Outcome
    IncreaseAntioxidant defenses
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin treatment significantly improved serum testosterone, sperm characteristics, and antioxidant defenses.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin decreased active caspase-3 in the testis.

    In plain wordsIn aged male rats with low testosterone, humanin lowered active caspase-3, a cell death marker.

    Peptide
    Humanin
    Outcome
    DecreaseActive caspase-3
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It decreased active caspase-3, pro-apoptotic BAX expression, and increased antiapoptotic BCL2 and proliferating cell nuclear antigen (PCNA) possibly via activating the (Nrf2- ARE) pathway.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin decreased pro-apoptotic BAX expression.

    In plain wordsIn aged male rats with low testosterone, humanin lowered BAX, a cell death marker.

    Peptide
    Humanin
    Outcome
    DecreaseBAX expression
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It decreased active caspase-3, pro-apoptotic BAX expression, and increased antiapoptotic BCL2 and proliferating cell nuclear antigen (PCNA) possibly via activating the (Nrf2- ARE) pathway.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin increased antiapoptotic BCL2.

    In plain wordsIn aged male rats with low testosterone, humanin raised BCL2, a cell survival marker.

    Peptide
    Humanin
    Outcome
    IncreaseBCL2 expression
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It decreased active caspase-3, pro-apoptotic BAX expression, and increased antiapoptotic BCL2 and proliferating cell nuclear antigen (PCNA) possibly via activating the (Nrf2- ARE) pathway.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats with late-onset hypogonadism, humanin increased proliferating cell nuclear antigen (PCNA).

    In plain wordsIn aged male rats with low testosterone, humanin raised PCNA, a cell growth marker.

    Peptide
    Humanin
    Outcome
    IncreasePCNA expression
    Study

    ratn: not reported in source

    aged male rats with declined serum testosterone (late-onset hypogonadism model)
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It decreased active caspase-3, pro-apoptotic BAX expression, and increased antiapoptotic BCL2 and proliferating cell nuclear antigen (PCNA) possibly via activating the (Nrf2- ARE) pathway.
    2 context sentences
    Summary · context
    Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group.
    Summary · context
    Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.