Study · In vitro (cells) · 2022
9 resultsHu Y, Jo H, DeGrado WF, Wang J
Journal of medical virology2 Feb 2022Cited by 42 (Europe PMC)
The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)
Text rights: Publisher copyright. Results still quote short attributed sentences.
8 results from studies that gave the peptide. No result from this study comes from people.
In cells, brilacidin inhibited SARS-CoV-2 pseudovirus entry into multiple cell lines.
In plain wordsIn cells, brilacidin inhibited SARS-CoV-2 pseudovirus entry.
n: not reported in source
Cell culturesSource sentences
Brilacidin, but not acetyl brilacidin, inhibits the entry of SARS-CoV-2 pseudovirus into multiple cell lines
In cells, brilacidin showed antiviral activity against HCoV-229E.
In plain wordsIn cells, brilacidin showed activity against HCoV-229E.
n: not reported in source
Cell culturesSource sentences
In addition, we found that brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses (HCoVs) including HCoV-229E, HCoV-OC43, and HCoV-NL63.
In cells, brilacidin showed antiviral activity against HCoV-OC43.
In plain wordsIn cells, brilacidin showed activity against HCoV-OC43.
n: not reported in source
Cell culturesSource sentences
In addition, we found that brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses (HCoVs) including HCoV-229E, HCoV-OC43, and HCoV-NL63.
In cells, brilacidin showed antiviral activity against HCoV-NL63.
In plain wordsIn cells, brilacidin showed activity against HCoV-NL63.
n: not reported in source
Cell culturesSource sentences
In addition, we found that brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses (HCoVs) including HCoV-229E, HCoV-OC43, and HCoV-NL63.
In lab tests, brilacidin showed virucidal activity.
In plain wordsIn lab tests, brilacidin directly inactivated viruses.
n: not reported in source
Cell culturesSource sentences
Mechanistic studies revealed that brilacidin has a dual antiviral mechanism of action including virucidal activity and binding to coronavirus attachment factor HSPGs on the host cell surface.
In cells, brilacidin bound coronavirus attachment factor HSPGs on the host cell surface.
In plain wordsIn cells, brilacidin bound host surface factors that help coronaviruses attach.
n: not reported in source
Cell culturesSource sentences
Mechanistic studies revealed that brilacidin has a dual antiviral mechanism of action including virucidal activity and binding to coronavirus attachment factor HSPGs on the host cell surface.
In cells, brilacidin partially lost antiviral activity when heparin was present.
In plain wordsIn cells, brilacidin lost part of its antiviral activity when heparin was present.
n: not reported in source
Cell culturesSource sentences
Brilacidin partially loses its antiviral activity when heparin was included in the cell cultures, supporting the host-targeting mechanism.
In cells, heparin abolished brilacidin inhibition of SARS-CoV-2 pseudovirus entry.
In plain wordsIn cells, heparin abolished brilacidin's ability to inhibit SARS-CoV-2 pseudovirus entry.
n: not reported in source
Multiple cell linesSource sentences
Brilacidin, but not acetyl brilacidin, inhibits the entry of SARS-CoV-2 pseudovirus into multiple cell lines, and heparin, an HSPG mimetic, abolishes the inhibitory activity of brilacidin on SARS-CoV-2 pseudovirus cell entry.
In this study, Brilacidin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Brilacidin.
In cells, brilacidin combined with remdesivir showed strong synergistic activity against HCoV-OC43.
In plain wordsIn cells, brilacidin combined with remdesivir showed strong synergistic activity against HCoV-OC43.
n: not reported in source
Cell culturesSource sentences
Drug combination therapy showed that brilacidin has a strong synergistic effect with remdesivir against HCoV-OC43 in cell culture.
In this study, Brilacidin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Brilacidin.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.
Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC
Terms as the source lists them.
PepBank is a research reference. Talk to a doctor before you use any peptide.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated