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Study · Animal study (in vivo) · mouse · 2022

1 result

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain.

Ramanathan C, Lackie T, Williams DH, Simone PS, Zhang Y, Bloomer RJ

Nutrients12 Jan 2022Cited by 23 (Europe PMC)

PMID35057482 (opens in a new tab)PMCIDPMC8778478 (opens in a new tab)DOI10.3390/nu14020300 (opens in a new tab)PepBankPUB-35057482
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Summary

As a redox-sensitive coenzyme, nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular energy metabolism and homeostasis. Low NAD+ levels are linked to multiple disease states, including age-related diseases, such as metabolic and neurodegenerative diseases. Consequently, restoring/increasing NAD+ levels in vivo has emerged as an important intervention targeting age-related neurodegenerative diseases. One of the widely studied approaches to increase NAD+ levels in vivo is accomplished by using NAD+ precursors, such as nicotinamide mononucleotide (NMN). Oral administration of NMN has been shown to successfully increase NAD+ levels in a variety of tissues; however, it remains unclear whether NMN can cross the blood-brain barrier to increase brain NAD+ levels. This study evaluated the effects of oral NMN administration on NAD+ levels in C57/B6J mice brain tissues. Our results demonstrate that oral gavage of 400 mg/kg NMN successfully increases brain NAD+ levels in mice after 45 min. These findings provide evidence that NMN may be used as an intervention to increase NAD+ levels in the brain.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mice, oral NMN increased brain NAD+ levels after 45 min.

    In plain wordsIn mice, oral NMN increased brain NAD+ levels after 45 min.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBrain NAD+ levels
    Study

    mousen: not reported in source

    C57/B6J mice
    Outcome group
    Metabolic pathways and metabolomics · Nervous system and cognition
    Studied dose
    400 mg/kg · oral gavage · 45 minAs given in this study (mouse).

    Source sentences

    Summary
    Our results demonstrate that oral gavage of 400 mg/kg NMN successfully increases brain NAD+ levels in mice after 45 min.
    1 context sentence
    Summary · context
    This study evaluated the effects of oral NMN administration on NAD+ levels in C57/B6J mice brain tissues.

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Version history

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  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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