Silk fibroin double-layer microneedles for the encapsulation and controlled release of triptorelin.

Lu X, Sun Y, Han M, Chen D, Wang A, Sun K

International journal of pharmaceutics28 Dec 2021Cited by 22 (Europe PMC)

PMID34968682DOI10.1016/j.ijpharm.2021.121433PepBankPUB-34968682

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In rats, triptorelin silk fibroin microneedles suppressed testosterone to castration levels for ≥7 d.
In plain wordsIn rats, triptorelin microneedles kept testosterone at castration levels for ≥7 d.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseTestosterone suppression to castration levels
Study
ratn: not reported in source
Rats given silk fibroin microneedles
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · transdermalAs given in this study (rat).
Measurements
Castration-level duration
≥ 7 d
rats
Source sentences
Summary
After administration to rats, SF-MNs exhibited long-term testosterone inhibition and maintained castration levels for ≥7 d.
Report a problemFND-3496868205

Studies that did not test the peptide alone4

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

02LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Other
In lab tests, triptorelin was encapsulated as microcrystals of approximately one micrometre in silk fibroin microneedles.
In plain wordsIn lab tests, silk fibroin microneedles held triptorelin microcrystals of approximately one micrometre.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableEncapsulated microcrystal size
Study
n: not reported in source
Silk fibroin microneedles
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Microcrystal size
≈ 1 μm
triptorelin in microneedles
Source sentences
Summary
Triptorelin was wrapped in MNs in the form of microcrystals with a size of ∼1 μm.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3496868201
03LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Pharmacokinetics
In lab tests, microneedles released triptorelin in phosphate-buffered saline for 168 h.
In plain wordsIn lab tests, microneedles released triptorelin in saline for 168 h.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableSustained release
Study
n: not reported in source
Phosphate-buffered saline
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Release duration
168 h
phosphate-buffered saline
Source sentences
Summary
The triptorelin in MNs could be released sustainedly in phosphate-buffered saline for 168 h, and the release amount decreased with increasing β-sheet content.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3496868202
04LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Pharmacokinetics
In lab tests, triptorelin release from microneedles decreased as silk fibroin β-sheet content increased.
In plain wordsIn lab tests, microneedles released less triptorelin when silk fibroin β-sheet content increased.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseRelease amount versus β-sheet content
Study
n: not reported in source
Phosphate-buffered saline
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The triptorelin in MNs could be released sustainedly in phosphate-buffered saline for 168 h, and the release amount decreased with increasing β-sheet content.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3496868203
05LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Pharmacokinetics
In lab tests, the triptorelin diffusion coefficient decreased linearly with increased β-sheet content in silk fibroin microneedles.
In plain wordsIn lab tests, triptorelin diffused more slowly from microneedles as β-sheet content increased.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDiffusion coefficient versus β-sheet content
Study
n: not reported in source
Silk fibroin microneedles
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
A linear decreasing relationship was observed between the diffusion coefficient and increased β-sheet content.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3496868204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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