Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study.

Ramzan F, Qureshi IZ, Ramzan MH

Protein and peptide letters1 Jan 2022

PMID34961438DOI10.2174/0929866528666211213090033PepBankPUB-34961438

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, 1 ηg kisspeptin‑10 twice daily reduced plasma testosterone versus control (P<0.05).
In plain wordsIn young male rats, a low dose of kisspeptin‑10 lowered blood testosterone compared with control.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma testosterone
Study
rat (Sprague-Dawley)n: not reported in source
prepubertal male rats (PND 35)
Comparator
Saline control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 ηg · intraperitonealAs given in this study (rat (Sprague-Dawley)).
Source sentences
Summary
Plasma testosterone concentration was reduced significantly at 1ηg (P<0.05) and 1μg (P<0.01) doses as compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.
Summary · context
Control rats were injected with physiological saline in parallel.
Report a problemFND-3496143801
02AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, 1 μg kisspeptin‑10 twice daily reduced plasma testosterone versus control (P<0.01).
In plain wordsIn young male rats, a higher dose of kisspeptin‑10 lowered blood testosterone compared with control.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma testosterone
Study
rat (Sprague-Dawley)n: not reported in source
prepubertal male rats (PND 35)
Comparator
Saline control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 μg · intraperitonealAs given in this study (rat (Sprague-Dawley)).
Source sentences
Summary
Plasma testosterone concentration was reduced significantly at 1ηg (P<0.05) and 1μg (P<0.01) doses as compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.
Summary · context
Control rats were injected with physiological saline in parallel.
Report a problemFND-3496143802
03AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin‑10 caused ultrastructural changes in Leydig cells, including organelle dilatation, irregular nuclei, degeneration and vacuolation, versus control.
In plain wordsIn young male rats, kisspeptin‑10 damaged the structure of testosterone-making testis cells compared with control.
Peptide
Kisspeptin-10
Outcome
IncreaseLeydig cell ultrastructural degeneration
Study
rat (Sprague-Dawley)n: not reported in source
prepubertal male rats (PND 35)
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg, 1 ηg and 10 ρg · intraperitonealAs given in this study (rat (Sprague-Dawley)).
Source sentences
Summary
Distinct ultrastructural changes categorized as dilatation of cytoplasmic organelles, irregularly shaped nuclei with nuclear membrane invaginations, reduced nuclear sizes, degeneration, and vacuolation were observed in the kisspeptin-10 treated Leydig cells as compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.
Summary · context
Control rats were injected with physiological saline in parallel.
Report a problemFND-3496143803
04AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin‑10 reduced Leydig cell indices.
In plain wordsIn young male rats, kisspeptin‑10 lowered Leydig cell measures in the testis.
Peptide
Kisspeptin-10
Outcome
DecreaseLeydig cell indices
Study
rat (Sprague-Dawley)n: not reported in source
prepubertal male rats (PND 35)
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg, 1 ηg and 10 ρg · intraperitonealAs given in this study (rat (Sprague-Dawley)).
Source sentences
Summary
Quantification of the data showed reduced Leydig cell indices
2 context sentences(design, population, supporting numbers)
Summary · context
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.
Summary · context
Control rats were injected with physiological saline in parallel.
Report a problemFND-3496143804
05AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin‑10 was followed by hyperplasia of the interstitial cells of the testis.
In plain wordsIn young male rats, kisspeptin‑10 was followed by overgrowth of interstitial cells in the testis.
Peptide
Kisspeptin-10
Outcome
IncreaseInterstitial cell hyperplasia
Study
rat (Sprague-Dawley)n: not reported in source
prepubertal male rats (PND 35)
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg, 1 ηg and 10 ρg · intraperitonealAs given in this study (rat (Sprague-Dawley)).
Source sentences
Summary
hyperplasia of the interstitial cells.
2 context sentences(design, population, supporting numbers)
Summary · context
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.
Summary · context
Control rats were injected with physiological saline in parallel.
Report a problemFND-3496143805

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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