Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.

Fatima I, Qureshi IZ

Andrologia12 Dec 2021Cited by 2 (Europe PMC)

PMID34897760DOI10.1111/and.14347PepBankPUB-34897760

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 increased the activity of antioxidant enzymes (p < 0.001).
In plain wordsIn mice given arsenic, kisspeptin‑10 raised antioxidant enzyme activity compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
IncreaseAntioxidant enzyme activity
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Oxidative stress · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
This was indicated by an increase (p < 0.001) in the activity of antioxidant enzymes and a decrease (p < 0.001) in the levels of oxidative stress biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776001
02AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 decreased oxidative stress biomarker levels (p < 0.001).
In plain wordsIn mice given arsenic, kisspeptin‑10 lowered oxidative stress markers compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
DecreaseOxidative stress biomarkers
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Oxidative stress · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
This was indicated by an increase (p < 0.001) in the activity of antioxidant enzymes and a decrease (p < 0.001) in the levels of oxidative stress biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776002
03AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 increased relative organ weight (p < 0.01).
In plain wordsIn mice given arsenic, kisspeptin‑10 increased reproductive organ weight compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
IncreaseRelative reproductive organ weight
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Concomitant significant increase was noticeable in the relative organ weight (p < 0.01), and serum testosterone and seminal fructose (p < 0.001), and a significant improvement in sperm parameters was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776003
04AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 increased serum testosterone (p < 0.001).
In plain wordsIn mice given arsenic, kisspeptin‑10 raised blood testosterone compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum testosterone
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Concomitant significant increase was noticeable in the relative organ weight (p < 0.01), and serum testosterone and seminal fructose (p < 0.001), and a significant improvement in sperm parameters was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776004
05AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 increased seminal fructose (p < 0.001).
In plain wordsIn mice given arsenic, kisspeptin‑10 raised seminal fructose compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSeminal fructose
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Concomitant significant increase was noticeable in the relative organ weight (p < 0.01), and serum testosterone and seminal fructose (p < 0.001), and a significant improvement in sperm parameters was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776005
06AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 significantly improved sperm parameters.
In plain wordsIn mice given arsenic, kisspeptin‑10 improved sperm measures compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSperm parameters
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Concomitant significant increase was noticeable in the relative organ weight (p < 0.01), and serum testosterone and seminal fructose (p < 0.001), and a significant improvement in sperm parameters was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776006
07AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, kisspeptin‑10 significantly decreased lactate dehydrogenase concentration, a marker of tissue damage.
In plain wordsIn mice given arsenic, kisspeptin‑10 lowered a marker of tissue damage compared with arsenic alone.
Peptide
Kisspeptin-10
Outcome
DecreaseLactate dehydrogenase concentration
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
A significant downregulation of lactate dehydrogenase concentration demonstrated further the protective effect of kisspeptin against tissue damage.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776007
08AnimalAnimal study (in vivo)Efficacy outcome
In male mice exposed to sodium arsenite, both kisspeptin‑10 regimens prevented massive germ cell loss and tissue damage seen with arsenite alone.
In plain wordsIn mice given arsenic, kisspeptin‑10 prevented the testis cell loss and damage seen with arsenic alone.
Peptide
Kisspeptin-10
Outcome
DecreaseGerm cell loss and tissue damage (histology)
Study
mousen: not reported in source
adult male mice with sodium arsenite-induced reproductive toxicity
Comparator
Sodium arsenite alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 nmol/day · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Histologically, both treatment regimens of kisspeptin combined with sodium arsenite exposure prevented massive germ cell loss and tissue damage, a condition prominent in sodium arsenite-alone-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.
Summary · context
Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups.
Report a problemFND-3489776008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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