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Study · Animal study (in vivo) · mouse · 2022

8 results

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.

Jiang B, Wang M, Li X, Ren P, Li G, Wang Y, Wang L, Li X, Yang D, Qin L, Xin S

Microvascular research29 Nov 2021Cited by 5 (Europe PMC)

PMID34856183 (opens in a new tab)DOI10.1016/j.mvr.2021.104280 (opens in a new tab)PepBankPUB-34856183
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin decreased infrarenal aorta diameter.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin reduced the width of the aorta below the kidneys.

    Peptide
    Hexarelin
    Outcome
    DecreaseInfrarenal aorta diameter
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    Echocardiography and in situ pictures showed hexarelin decreased infrarenal aorta diameter.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with elastase-induced abdominal aortic aneurysm, elastin degradation was improved in the hexarelin-treated group.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin treatment reduced breakdown of elastin in the aortic wall.

    Peptide
    Hexarelin
    Outcome
    DecreaseElastin degradation
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    Histology staining showed elastin degradation was improved in hexarelin-treated group.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin rescued the smooth muscle cell contractile phenotype with increased α-SMA.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin restored the contractile type of smooth muscle cells, with higher α-SMA.

    Peptide
    Hexarelin
    Outcome
    Increaseα-SMA expression (smooth muscle contractile phenotype)
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    Hexarelin rescued smooth muscle cell contractile phenotype with increased α-SMA
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin decreased MMP2.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin lowered MMP2 levels.

    Peptide
    Hexarelin
    Outcome
    DecreaseMMP2 expression
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    decreased MMP2.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin inhibited inflammatory cell infiltration.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin reduced the arrival of inflammatory cells in the aortic wall.

    Peptide
    Hexarelin
    Outcome
    DecreaseInflammatory cell infiltration
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    inhibited inflammatory cell infiltration, NLRP3 inflammasome activation and IL-18 production.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin inhibited NLRP3 inflammasome activation.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin reduced activation of the NLRP3 inflammasome, an inflammatory signalling complex.

    Peptide
    Hexarelin
    Outcome
    DecreaseNLRP3 inflammasome activation
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    NLRP3 inflammasome activation and IL-18 production.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin inhibited IL-18 production.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin reduced production of IL-18, an inflammatory signal.

    Peptide
    Hexarelin
    Outcome
    DecreaseIL-18 production
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    IL-18 production.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with elastase-induced abdominal aortic aneurysm, hexarelin suppressed the NF-κB signaling pathway.

    In plain wordsIn mice with an induced aortic aneurysm, hexarelin suppressed NF-κB signalling, a key starter of inflammation.

    Peptide
    Hexarelin
    Outcome
    DecreaseNF-κB signaling
    Study

    mousen: not reported in source

    Elastase-induced abdominal aortic aneurysm
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    200 μg/kg twice per dayAs given in this study (mouse).

    Source sentences

    Summary
    Particularly, hexarelin suppressed NF-κB signaling pathway which is a key initiator of inflammatory response.
    1 context sentence
    Summary · context
    The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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