Pretreatment with nicotinamide mononucleotide increases the effect of ischaemic postconditioning on cardioprotection and mitochondrial function following ex vivo myocardial reperfusion injury in aged rats.

Rajabi M, Vafaee MS, Hosseini L, Badalzadeh R

Clinical and experimental pharmacology & physiology9 Feb 2022Cited by 5 (Europe PMC)

PMID34854121DOI10.1111/1440-1681.13616PepBankPUB-34854121

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, NMN reduced lactate dehydrogenase release versus control.
In plain wordsIn rats, NMN reduced lactate dehydrogenase release compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseLactate dehydrogenase release
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
The results showed that all treatments reduced lactate dehydrogenase release compared to those of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412101
02AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, NMN improved myocardial function versus control.
In plain wordsIn rats, NMN improved heart function compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMyocardial function
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
However, NMN and combined therapy could significantly improve myocardial function and decrease the IS compared to the control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412103
03AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, NMN decreased infarct size versus control.
In plain wordsIn rats, NMN reduced infarct size compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInfarct size
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
However, NMN and combined therapy could significantly improve myocardial function and decrease the IS compared to the control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412104
04AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, adding NMN to ischaemic postconditioning reduced infarct size more than postconditioning alone.
In plain wordsIn rats, adding NMN to ischaemic postconditioning reduced infarct size more than postconditioning alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInfarct size
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Ischaemic postconditioning alone
Outcome group
Heart function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412108
05AnimalAnimal study (in vivo)Mechanism
In aged rats, adding NMN to ischaemic postconditioning reduced mitochondrial ROS more than postconditioning alone.
In plain wordsIn rats, adding NMN to ischaemic postconditioning reduced mitochondrial ROS more than postconditioning alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMitochondrial ROS
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Ischaemic postconditioning alone
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412110
06AnimalAnimal study (in vivo)Mechanism
In aged rats, adding NMN to ischaemic postconditioning improved mitochondrial membrane potential more than postconditioning alone.
In plain wordsIn rats, adding NMN to ischaemic postconditioning improved mitochondrial membrane potential more than postconditioning alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial membrane potential
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Ischaemic postconditioning alone
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
100 mg/kg every other day · intraperitoneal · 28 daysAs given in this study (rat).
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
Report a problemFND-3485412112

Studies that did not test the peptide alone6

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

07AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats, NMN plus ischaemic postconditioning reduced lactate dehydrogenase release versus control.
In plain wordsIn rats, NMN plus ischaemic postconditioning reduced lactate dehydrogenase release compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseLactate dehydrogenase release
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
The results showed that all treatments reduced lactate dehydrogenase release compared to those of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412102
08AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats, NMN plus ischaemic postconditioning improved myocardial function versus control.
In plain wordsIn rats, NMN plus ischaemic postconditioning improved heart function compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMyocardial function
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
However, NMN and combined therapy could significantly improve myocardial function and decrease the IS compared to the control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412105
09AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats, NMN plus ischaemic postconditioning decreased infarct size versus control.
In plain wordsIn rats, NMN plus ischaemic postconditioning reduced infarct size compared with control.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInfarct size
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
Control
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
However, NMN and combined therapy could significantly improve myocardial function and decrease the IS compared to the control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412106
10AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats, combined NMN and ischaemic postconditioning reduced infarct size more than NMN alone.
In plain wordsIn rats, NMN plus ischaemic postconditioning reduced infarct size more than NMN alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInfarct size
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
NMN alone
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412107
11AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aged rats, NMN plus ischaemic postconditioning reduced mitochondrial ROS more than NMN alone.
In plain wordsIn rats, NMN plus ischaemic postconditioning reduced mitochondrial ROS more than NMN alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMitochondrial ROS
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
NMN alone
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412109
12AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism
In aged rats, NMN plus ischaemic postconditioning improved mitochondrial membrane potential more than NMN alone.
In plain wordsIn rats, NMN plus ischaemic postconditioning improved mitochondrial membrane potential more than NMN alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial membrane potential
Study
ratn: not reported in source
Aged Wistar rats with myocardial ischaemia-reperfusion injury
Comparator
NMN alone
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Moreover, the effects of combined therapy on the decrease of IS, mitochondrial reactive oxygen species (ROS), and improvement of mitochondrial membrane potential (MMP) were greater than those of stand-alone treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty aged Wistar rats were randomly divided into five groups (n = 12), including sham, control, NMN, IPostC, and NMN + IPostC.
Summary · context
NMN (100 mg/kg) was intraperitoneally injected every other day for 28 days before IR.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3485412111

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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