Triptorelin stimulated luteinizing hormone concentrations for diagnosing central precocious puberty: study of diagnostic accuracy.

Vukovic R, Milenkovic T, Soldatovic I, Pekic S, Mitrovic K, Todorovic S

Endocrine26 Nov 2021Cited by 14 (Europe PMC)

PMID34826116PMCIDPMC8616750DOI10.1007/s12020-021-02947-zPepBankPUB-34826116

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

01HumanObservational studyActivity measurement
In girls with premature thelarche, LH peaked 180 min after triptorelin injection.
In plain wordsIn girls with premature thelarche, LH peaked 180 min after triptorelin injection.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableLH peak timing
Study
n = 60
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Measurements
LH peak time
180 min
after triptorelin
Source sentences
Summary
LH peaked at 180 min after the triptorelin injection.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, case-control (CPP vs isolated premature thelarche), clinical study evaluating the diagnostic accuracy of triptorelin-stimulated LH concentrations in 60 girls with premature thelarche was performed.
Summary · context
All girls underwent stimulation with subcutaneous triptorelin injection and intravenous GnRH in a randomized order.
Report a problemFND-3482611602

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature thelarche, triptorelin-stimulated LH was higher in those with CPP than those without CPP.
In plain wordsIn girls with premature thelarche, triptorelin-stimulated LH was higher with CPP than without CPP.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseStimulated LH by CPP status
Study
n = 60
Comparator
Isolated premature thelarche
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Triptorelin-stimulated LH concentrations were significantly higher in girls who had CPP according to the GnRH test (53.3%).
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, case-control (CPP vs isolated premature thelarche), clinical study evaluating the diagnostic accuracy of triptorelin-stimulated LH concentrations in 60 girls with premature thelarche was performed.
Summary · context
All girls underwent stimulation with subcutaneous triptorelin injection and intravenous GnRH in a randomized order.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3482611601
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyOther
In girls with premature thelarche, triptorelin-stimulated LH at 180 min gave AUC 0.973, sensitivity 96.9%, and specificity 89.3% at ≥3.4 IU/L.
In plain wordsIn girls with premature thelarche, triptorelin-stimulated LH at 180 min had high diagnostic accuracy against the GnRH test.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableCPP diagnostic accuracy
Study
n = 60
Comparator
GnRH test
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Optimal LH cutoff at 180 min
≥ 3.4 IU/L
CPP diagnosis, triptorelin-stimulated
AUC
0.973 unitless
CPP diagnosis
Sensitivity
96.9%
CPP diagnosis
Specificity
89.3%
CPP diagnosis
Source sentences
Summary
The highest diagnostic accuracy for CPP (AUC = 0.973, sensitivity 96.9%, specificity 89.3%) at 180 min was at a LH concentration ≥3.4 IU/L.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, case-control (CPP vs isolated premature thelarche), clinical study evaluating the diagnostic accuracy of triptorelin-stimulated LH concentrations in 60 girls with premature thelarche was performed.
Summary · context
All girls underwent stimulation with subcutaneous triptorelin injection and intravenous GnRH in a randomized order.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3482611603

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.