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Study · Animal study (in vivo) · mouse · 2022

14 results

Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice.

Huang P, Zhou Y, Tang W, Ren C, Jiang A, Wang X, Qian X, Zhou Z, Gong A

The Journal of nutritional biochemistry19 Nov 2021Cited by 65 (Europe PMC)

PMID34801690 (opens in a new tab)DOI10.1016/j.jnutbio.2021.108911 (opens in a new tab)PepBankPUB-34801690
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN reduced aging effects on organ structures compared with water controls.

    In plain wordsIn aged female mice, NMN reduced aging effects on organ structures compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOrgan structure aging
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    First, we found that 20-week-long administration of NMN to 40-week-old mice exhibited anti-aging and anti-inflammatory effects on organ structures, along with the improvement of estrus cycle condition and endocrine function.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN reduced organ inflammation compared with water controls.

    In plain wordsIn aged female mice, NMN reduced organ inflammation compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOrgan inflammation
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    First, we found that 20-week-long administration of NMN to 40-week-old mice exhibited anti-aging and anti-inflammatory effects on organ structures, along with the improvement of estrus cycle condition and endocrine function.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN improved estrus cycle condition compared with water controls.

    In plain wordsIn aged female mice, NMN improved the reproductive cycle compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedEstrus cycle
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    First, we found that 20-week-long administration of NMN to 40-week-old mice exhibited anti-aging and anti-inflammatory effects on organ structures, along with the improvement of estrus cycle condition and endocrine function.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN improved endocrine function compared with water controls.

    In plain wordsIn aged female mice, NMN improved endocrine function compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEndocrine function
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    First, we found that 20-week-long administration of NMN to 40-week-old mice exhibited anti-aging and anti-inflammatory effects on organ structures, along with the improvement of estrus cycle condition and endocrine function.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN significantly increased primordial follicles compared with water controls.

    In plain wordsIn aged female mice, NMN increased primordial follicles compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePrimordial follicle count
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The number of primordial, primary, secondary, antral follicles and corpora luteum of ovaries in 60WN group was significantly increased compared with those in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN significantly increased primary follicles compared with water controls.

    In plain wordsIn aged female mice, NMN increased primary follicles compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePrimary follicle count
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The number of primordial, primary, secondary, antral follicles and corpora luteum of ovaries in 60WN group was significantly increased compared with those in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN significantly increased secondary follicles compared with water controls.

    In plain wordsIn aged female mice, NMN increased secondary follicles compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSecondary follicle count
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The number of primordial, primary, secondary, antral follicles and corpora luteum of ovaries in 60WN group was significantly increased compared with those in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN significantly increased antral follicles compared with water controls.

    In plain wordsIn aged female mice, NMN increased antral follicles compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAntral follicle count
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The number of primordial, primary, secondary, antral follicles and corpora luteum of ovaries in 60WN group was significantly increased compared with those in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, NMN significantly increased corpora luteum compared with water controls.

    In plain wordsIn aged female mice, NMN increased corpora luteum compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCorpora luteum count
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The number of primordial, primary, secondary, antral follicles and corpora luteum of ovaries in 60WN group was significantly increased compared with those in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In aged female mice, NMN significantly reduced ovarian P16 protein expression compared with water controls.

    In plain wordsIn aged female mice, NMN reduced ovarian P16 protein compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian P16 protein
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the protein and gene expressions of P16 of ovaries were significantly reduced in 60WN group than in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In aged female mice, NMN significantly reduced ovarian P16 gene expression compared with water controls.

    In plain wordsIn aged female mice, NMN reduced ovarian P16 gene expression compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian P16 gene expression
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the protein and gene expressions of P16 of ovaries were significantly reduced in 60WN group than in 60WC group.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In aged female mice, NMN enhanced mitochondrial biogenesis in granulosa cells compared with water controls.

    In plain wordsIn aged female mice, NMN increased mitochondrial biogenesis in granulosa cells compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGranulosa cell mitochondrial biogenesis
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    the mitochondria biogenesis, autophagy level, and proteases activity enhanced in granulosa cells after 20-week-administration of NMN.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  13. 13AnimalAnimal study (in vivo)Mechanism

    In aged female mice, NMN enhanced granulosa cell autophagy compared with water controls.

    In plain wordsIn aged female mice, NMN increased granulosa cell autophagy compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGranulosa cell autophagy
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    the mitochondria biogenesis, autophagy level, and proteases activity enhanced in granulosa cells after 20-week-administration of NMN.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).
  14. 14AnimalAnimal study (in vivo)Mechanism

    In aged female mice, NMN enhanced granulosa cell protease activity compared with water controls.

    In plain wordsIn aged female mice, NMN increased granulosa cell protease activity compared with water controls.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGranulosa cell protease activity
    Study

    mousen: not reported in source

    aged female ICR mice
    Comparator
    Water-treated aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 20 weeksAs given in this study (mouse).

    Source sentences

    Summary
    the mitochondria biogenesis, autophagy level, and proteases activity enhanced in granulosa cells after 20-week-administration of NMN.
    1 context sentence
    Summary · context
    In present study, 4, 8, 12, 24, 40-week old female ICR mice were collected and a 20-week-long administration of NMN was conducted to 40-week-old mice (60WN), meanwhile the control group is given water (60WC).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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