Skip to content

Study · In vitro (cells) · 2021

2 results

Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes.

Kong L, Moorlag SJCFM, Lefkovith A, Li B, Matzaraki V, van Emst L, Kang HA, Latorre I, Jaeger M, Joosten LAB, Netea MG, Xavier RJ

Cell reports1 Nov 2021Cited by 58 (Europe PMC)

PMID34788625 (opens in a new tab)PMCIDPMC8728743 (opens in a new tab)DOI10.1016/j.celrep.2021.110028 (opens in a new tab)PepBankPUB-34788625
Read at sourcePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In vitro, several humanin nuclear isoforms induced trained immunity.

    In plain wordsIn lab tests, several humanin variants triggered trained immunity.

    Peptide
    Humanin
    Outcome
    IncreaseInduction of trained immunity in vitro
    Study

    n: not reported in source

    In vitro trained immunity assay
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    several humanin nuclear isoforms that we confirm induce trained immunity in vitro.
    1 context sentence
    Summary · context
    To better understand BCG-induced immune reprogramming, we perform single-cell transcriptomic measurements before and after BCG vaccination using secondary immune stimulation with bacterial lipopolysaccharide (LPS).

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02HumanEndogenous levelNon-randomized trialOther

    In circulating monocytes after BCG vaccination, gene modules including several humanin nuclear isoforms showed increased coordination.

    In plain wordsAfter BCG vaccination, the body's own humanin gene variants in blood monocytes were more tightly co-regulated.

    Peptide
    Humanin
    Outcome
    IncreaseCo-expression of humanin nuclear isoforms after BCG
    Study

    n: not reported in source

    Circulating monocytes, single-cell transcriptomics
    Comparator
    Before BCG vaccination
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Other modules exhibit increased coordination, including several humanin nuclear isoforms
    1 context sentence
    Summary · context
    To better understand BCG-induced immune reprogramming, we perform single-cell transcriptomic measurements before and after BCG vaccination using secondary immune stimulation with bacterial lipopolysaccharide (LPS).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.