Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells.

Fang T, Yang J, Liu L, Xiao H, Wei X

MedComm27 May 2021Cited by 19 (Europe PMC)

PMID34766147PMCIDPMC8491199DOI10.1002/mco2.62PepBankPUB-34766147

Summary

Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. Investigating the mechanisms of ACE senescence is important for understanding how the human respiratory system works. NAD⁺ is reported to reduce during the aging process. Supplementing NAD⁺ intermediates can activate sirtuin deacylases (SIRT1-SIRT7), which regulates the benefits of exercise and dietary restriction, reduce the level of intracellular oxidative stress, and improve mitochondrial function, thereby reversing cell senescence. We showed that nicotinamide mononucleotide (NMN) could effectively mitigate age-associated physiological decline in the lung of 8-10 months old C57BL/6 mice and bleomycin-induced pulmonary fibrosis in young mice of 6-8 weeks. Besides, the treatment of primary ACEs with NMN can markedly ameliorate cell senescence phenotype in vitro. These findings to improve the respiratory system function and reduce the incidence and mortality from respiratory diseases in the elderly are of great significance.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aging mice, NMN mitigated age-associated physiological decline in the lung.
In plain wordsIn mice, NMN reduced age-associated decline in lung physiology.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseAge-associated lung decline
Study
mousen: not reported in source
8-10 months old C57BL/6 mice
Outcome group
Aging markers · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
We showed that nicotinamide mononucleotide (NMN) could effectively mitigate age-associated physiological decline in the lung of 8-10 months old C57BL/6 mice and bleomycin-induced pulmonary fibrosis in young mice of 6-8 weeks.
Show in the study text Report a problemFND-3476614701
02AnimalAnimal study (in vivo)Efficacy outcome
In young mice, NMN mitigated bleomycin-induced pulmonary fibrosis.
In plain wordsIn young mice, NMN reduced lung fibrosis induced by bleomycin.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreasePulmonary fibrosis
Study
mousen: not reported in source
bleomycin-induced pulmonary fibrosis
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
We showed that nicotinamide mononucleotide (NMN) could effectively mitigate age-associated physiological decline in the lung of 8-10 months old C57BL/6 mice and bleomycin-induced pulmonary fibrosis in young mice of 6-8 weeks.
Show in the study text Report a problemFND-3476614702
03LabIn vitro (cells)Efficacy outcome
In primary alveolar epithelial cells, NMN markedly ameliorated the senescence phenotype.
In plain wordsIn cells, NMN reduced the senescence phenotype in primary alveolar epithelial cells.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCell senescence phenotype
Study
n: not reported in source
primary alveolar epithelial cells
Outcome group
Aging markers · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Besides, the treatment of primary ACEs with NMN can markedly ameliorate cell senescence phenotype in vitro.
Show in the study text Report a problemFND-3476614703

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.