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Study · Animal study (in vivo) · mouse · 2021

2 results

NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice.

Xu L, Yang C, Ma J, Zhang X, Wang Q, Xiong X

Human & experimental toxicology9 Nov 2021Cited by 9 (Europe PMC)

PMID34752167 (opens in a new tab)DOI10.1177/09603271211052991 (opens in a new tab)PepBankPUB-34752167
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to CCl4, NMN suppressed hepatic stellate cell activation.

    In plain wordsIn mice, NMN reduced hepatic stellate cell activation compared with CCl4 alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic stellate cell activation
    Study

    mousen: not reported in source

    CCl4-induced liver fibrosis
    Comparator
    CCl4 without NMN
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of NMN also suppresses HSC activation and protects against CCl4-induced liver fibrosis in mice.
    1 context sentence
    Summary · context
    Mouse liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) 2 times a week for 6 weeks. Adenovirus-mediated NAMPT overexpression or nicotinamide mononucleotide (NMN) administration was carried out to study the effects of elevation of NAD+ levels…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to CCl4, NMN protected against liver fibrosis.

    In plain wordsIn mice, NMN reduced liver fibrosis compared with CCl4 alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLiver fibrosis
    Study

    mousen: not reported in source

    CCl4-induced liver fibrosis
    Comparator
    CCl4 without NMN
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of NMN also suppresses HSC activation and protects against CCl4-induced liver fibrosis in mice.
    1 context sentence
    Summary · context
    Mouse liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) 2 times a week for 6 weeks. Adenovirus-mediated NAMPT overexpression or nicotinamide mononucleotide (NMN) administration was carried out to study the effects of elevation of NAD+ levels…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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