The effect of triptorelin and leuprolide on the level of sex hormones in girls with central precocious puberty and its clinical efficacy analysis.

Wang L, Jiang Q, Wang M, Xu J, Jin J

Translational pediatrics1 Sept 2021Cited by 5 (Europe PMC)

PMID34733671PMCIDPMC8506057DOI10.21037/tp-21-352PepBankPUB-34733671

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to lower estradiol levels than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to lower estradiol levels than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEstradiol levels
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, serum levels of E2 and FSH in the triptorelin group were lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367101
02HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to lower FSH levels than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to lower FSH levels than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH levels
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, serum levels of E2 and FSH in the triptorelin group were lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367102
03HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, LH levels did not differ significantly between triptorelin and leuprolide after treatment.
In plain wordsIn girls with early puberty, LH levels did not differ significantly between triptorelin and leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLH levels
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
There was no significant difference in LH levels between the two groups after 1 year of treatment (P>0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367103
04HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to lower ovarian volume than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to smaller ovarian volume than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOvarian volume
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, the ovarian volume, follicle diameter, and uterine volume of the girls in the triptorelin group were all lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367104
05HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to lower follicle diameter than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to smaller follicles than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFollicle diameter
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, the ovarian volume, follicle diameter, and uterine volume of the girls in the triptorelin group were all lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367105
06HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to lower uterine volume than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to smaller uterine volume than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine volume
Study
n = 128
Comparator
leuprolide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, the ovarian volume, follicle diameter, and uterine volume of the girls in the triptorelin group were all lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367106
07HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to a lower growth rate than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to slower growth than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseGrowth rate
Study
n = 128
Comparator
leuprolide
Outcome group
Linear growth · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, the growth rate and maturity of participants in the triptorelin group were lower than those in the leuprolide group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367107
08HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, triptorelin was linked to a lower maturity ratio than leuprolide after treatment.
In plain wordsIn girls with early puberty, triptorelin was linked to a lower maturity ratio than leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMaturity ratio
Study
n = 128
Comparator
leuprolide
Outcome group
Bone and joint · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
After 1 year of treatment, the growth rate and maturity of participants in the triptorelin group were lower than those in the leuprolide group (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The differences of serum sex hormone level, ovarian volume, uterine volume, follicle diameter, bone age, growth rate (height change within half a year), maturity (bone age/living age), and other aspects between the two groups of girls were compared.
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367108
09HumanObservational studyEfficacy outcome
In girls with idiopathic central precocious puberty, bone age did not differ significantly between triptorelin and leuprolide after treatment.
In plain wordsIn girls with early puberty, bone age did not differ significantly between triptorelin and leuprolide after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeBone age
Study
n = 128
Comparator
leuprolide
Outcome group
Bone and joint · Endocrine and hormones
Studied dose
Dose not stated · 1 yearAs given in this study (human).
Source sentences
Summary
There was no significant difference in bone age between the two groups after 1 year of treatment (P>0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Retrospective analysis was performed on 128 girls with ICPP who were diagnosed and treated in our hospital from January 2017 to January 2020, including 71 girls in the leuprolide group and 57 girls in the triptorelin group.
Report a problemFND-3473367109

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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