Bioprotective and Functional Effect of Carnosine on Sepsis Induced Renal Damage in Male Albino Rat Model through Targeting IL-1β and TNF-α Production.

Wang H, Fang Z, Qiu G, Zhang C, Tang M, Zhou B

Doklady. Biochemistry and biophysics1 Sept 2021Cited by 3 (Europe PMC)

PMID34697750DOI10.1134/s1607672921050033PepBankPUB-34697750

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine dose-dependently reduced serum urea nitrogen.
In plain wordsIn rats with acute kidney injury, carnosine reduced blood urea nitrogen compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseSerum urea nitrogen
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Treatment with carnosine suppressed AKI induced urea nitrogen and creatinine in Male Albino rat serum in dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine dose-dependently reduced serum creatinine.
In plain wordsIn rats with acute kidney injury, carnosine reduced blood creatinine compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Treatment with carnosine suppressed AKI induced urea nitrogen and creatinine in Male Albino rat serum in dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine prevented sepsis-mediated renal injury.
In plain wordsIn rats, carnosine reduced sepsis-related kidney injury compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseRenal injury
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Development of sepsis mediated renal injury in Albino rats was also effectively prevented on treatment with carnosine.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine significantly reduced renal IL-1β secretion.
In plain wordsIn rats with acute kidney injury, carnosine reduced kidney IL-1β secretion compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseRenal IL-1beta secretion
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Secretion of AKI-induced IL-1β, IL-18, and TNF-α in renal tissues was alleviated significantly in Albino rats by carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine significantly reduced renal IL-18 secretion.
In plain wordsIn rats with acute kidney injury, carnosine reduced kidney IL-18 secretion compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseRenal IL-18 secretion
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Secretion of AKI-induced IL-1β, IL-18, and TNF-α in renal tissues was alleviated significantly in Albino rats by carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine significantly reduced renal TNF-α secretion.
In plain wordsIn rats with acute kidney injury, carnosine reduced kidney TNF-α secretion compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseRenal TNF-alpha secretion
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Secretion of AKI-induced IL-1β, IL-18, and TNF-α in renal tissues was alleviated significantly in Albino rats by carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775006
07AnimalAnimal study (in vivo)Mechanism
In rats with AKI, carnosine reduced renal Bax expression compared with AKI rats.
In plain wordsIn rats with acute kidney injury, carnosine reduced kidney Bax expression compared with AKI rats.
Peptide
L-carnosine
Outcome
DecreaseRenal Bax expression
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Additionally, in carnosine-treated Albino rats renal tissues AKI induced Bax expression was alleviated while as Bcl-2 was promoted compared to AKI Albino rats.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775007
08AnimalAnimal study (in vivo)Mechanism
In rats with AKI, carnosine increased renal Bcl-2 expression compared with AKI rats.
In plain wordsIn rats with acute kidney injury, carnosine increased kidney Bcl-2 expression compared with AKI rats.
Peptide
L-carnosine
Outcome
IncreaseRenal Bcl-2 expression
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Additionally, in carnosine-treated Albino rats renal tissues AKI induced Bax expression was alleviated while as Bcl-2 was promoted compared to AKI Albino rats.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775008
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with AKI, carnosine improved survival rate.
In plain wordsIn rats with acute kidney injury, carnosine increased survival compared with AKI rats.
Peptide
L-carnosine
Outcome
IncreaseSurvival rate
Study
ratn: not reported in source
Cecal ligation and puncture-induced acute kidney injury
Comparator
AKI rats
Outcome group
Mortality · Whole body
Studied dose
Dose not stated
Source sentences
Summary
Carnosine treatment improved the survival rate of the Albino rats with AKI.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the bioprotective and functional effect of carnosine on AKI induced pathological damage in Male Albino rat model in vivo.
Summary · context
AKI in Albino rats was induced by cecal ligation and puncture surgery where as TNF-α and IL-1β levels were detected using ELISA assay.
Report a problemFND-3469775009

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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