β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice.

Zhou X, Du HH, Long X, Pan Y, Hu J, Yu J, Zhao X

Journal of inflammation research7 Oct 2021Cited by 27 (Europe PMC)

PMID34675595PMCIDPMC8504657DOI10.2147/jir.s327329PepBankPUB-34675595

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study26

26 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN blocked photodamage.
In plain wordsIn mice, NMN reduced skin damage compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreasePhotodamage
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559501
02AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained normal collagen fiber structure.
In plain wordsIn mice, NMN preserved normal collagen fiber structure compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableCollagen fiber structure
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559502
03AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained a normal amount of collagen fibers.
In plain wordsIn mice, NMN preserved normal collagen fiber amounts compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableCollagen fiber amount
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559503
04AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained normal epidermal thickness.
In plain wordsIn mice, NMN preserved normal epidermal thickness compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableEpidermal thickness
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559504
05AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained normal dermal thickness.
In plain wordsIn mice, NMN preserved normal dermal thickness compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableDermal thickness
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559505
06AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN reduced mast cell production.
In plain wordsIn mice, NMN reduced mast cell production compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMast cell production
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Immune response · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559506
07AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained complete organized skin structure.
In plain wordsIn mice, NMN preserved organized skin structure compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableOrganized skin structure
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559507
08AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN maintained normal liver morphology.
In plain wordsIn mice, NMN preserved normal liver structure compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableLiver morphology
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
NMN intraperitoneal injection also maintained the normal morphology of the mouse liver after UVB exposure.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559508
09AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN enhanced antioxidant enzyme activity in skin and liver.
In plain wordsIn mice, NMN increased antioxidant enzyme activity in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAntioxidant enzyme activity in skin and liver
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Meanwhile, NMN intraperitoneal injection was found to increase antioxidant ability and regulate the proinflammatory response of the skin and liver to UVB irradiation by enhancing the activity of antioxidant enzymes, release of anti-inflammatory cytokines, reduction of hydrogen peroxide production (H…
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559509
10AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN enhanced anti-inflammatory cytokine release in skin and liver.
In plain wordsIn mice, NMN increased anti-inflammatory cytokine release in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAnti-inflammatory cytokine release in skin and liver
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Meanwhile, NMN intraperitoneal injection was found to increase antioxidant ability and regulate the proinflammatory response of the skin and liver to UVB irradiation by enhancing the activity of antioxidant enzymes, release of anti-inflammatory cytokines, reduction of hydrogen peroxide production (H…
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559510
11AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN reduced hydrogen peroxide production in skin and liver.
In plain wordsIn mice, NMN reduced hydrogen peroxide production in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseHydrogen peroxide production in skin and liver
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Meanwhile, NMN intraperitoneal injection was found to increase antioxidant ability and regulate the proinflammatory response of the skin and liver to UVB irradiation by enhancing the activity of antioxidant enzymes, release of anti-inflammatory cytokines, reduction of hydrogen peroxide production (H…
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559511
12AnimalAnimal study (in vivo)Efficacy outcome
In UVB-exposed mice, NMN decreased inflammatory cytokines in skin and liver.
In plain wordsIn mice, NMN reduced inflammatory cytokines in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInflammatory cytokines in skin and liver
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Meanwhile, NMN intraperitoneal injection was found to increase antioxidant ability and regulate the proinflammatory response of the skin and liver to UVB irradiation by enhancing the activity of antioxidant enzymes, release of anti-inflammatory cytokines, reduction of hydrogen peroxide production (H…
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559512
13AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN reduced oxidative stress in skin and liver.
In plain wordsIn mice, NMN reduced oxidative stress in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseOxidative stress in skin and liver
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Furthermore, RT-qPCR results indicated that NMN reduced oxidative stress of skin and liver by promoting the activation of the AMP-activated protein kinase (AMPK) signaling pathway and further increasing the expression of downstream antioxidant genes of AMPK.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559513
14AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN promoted AMPK signaling activation in skin and liver.
In plain wordsIn mice, NMN increased AMPK signaling in skin and liver compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAMPK pathway activation
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Furthermore, RT-qPCR results indicated that NMN reduced oxidative stress of skin and liver by promoting the activation of the AMP-activated protein kinase (AMPK) signaling pathway and further increasing the expression of downstream antioxidant genes of AMPK.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559514
15AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased downstream antioxidant gene expression in the AMPK pathway.
In plain wordsIn mice, NMN increased AMPK-related antioxidant gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAMPK downstream antioxidant gene expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Furthermore, RT-qPCR results indicated that NMN reduced oxidative stress of skin and liver by promoting the activation of the AMP-activated protein kinase (AMPK) signaling pathway and further increasing the expression of downstream antioxidant genes of AMPK.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559515
16AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN reduced IL-6 mRNA expression.
In plain wordsIn mice, NMN reduced IL-6 gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-6 mRNA expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559516
17AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN reduced IL-1β mRNA expression.
In plain wordsIn mice, NMN reduced IL-1β gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-1β mRNA expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559517
18AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN reduced TNF-α mRNA expression.
In plain wordsIn mice, NMN reduced TNF-α gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseTNF-α mRNA expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559518
19AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased IκB-α mRNA expression.
In plain wordsIn mice, NMN increased IκB-α gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseIκB-α mRNA expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559519
20AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased IL-10 mRNA expression.
In plain wordsIn mice, NMN increased IL-10 gene expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseIL-10 mRNA expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559520
21AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN inhibited NFκB-p65 activation.
In plain wordsIn mice, NMN reduced NFκB-p65 activation compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseNFκB-p65 activation
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65).
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559521
22AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased skin AMPK protein expression.
In plain wordsIn mice, NMN increased skin AMPK protein expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin AMPK protein expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559522
23AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased skin IκB-α protein expression.
In plain wordsIn mice, NMN increased skin IκB-α protein expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin IκB-α protein expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559523
24AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased skin SOD1 protein expression.
In plain wordsIn mice, NMN increased skin SOD1 protein expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin SOD1 protein expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559524
25AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN increased skin CAT protein expression.
In plain wordsIn mice, NMN increased skin CAT protein expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin CAT protein expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559525
26AnimalAnimal study (in vivo)Mechanism
In UVB-exposed mice, NMN decreased skin NF-κBp65 protein expression.
In plain wordsIn mice, NMN reduced skin NF-κBp65 protein expression compared with UVB exposure alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseSkin NF-κBp65 protein expression
Study
mousen: not reported in source
UVB-induced photodamage
Comparator
UVB exposure without NMN
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (mouse).
Source sentences
Summary
Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results.
2 context sentences(design, population, supporting numbers)
Summary · context
This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage.
Summary · context
We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin- and liver-related genes.
Report a problemFND-3467559526

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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