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Study · Animal study (in vivo) · mouse · 2021

2 results

Carnosine and skeletal muscle dysfunction in a rodent multiple sclerosis model.

Spaas J, Van Noten P, Keytsman C, Nieste I, Blancquaert L, Derave W, Eijnde BO

Amino acids12 Oct 2021Cited by 9 (Europe PMC)

PMID34642824 (opens in a new tab)DOI10.1007/s00726-021-03086-5 (opens in a new tab)PepBankPUB-34642824
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, oral carnosine dose-dependently increased muscle carnosine levels up to +94% after 56 days EAE.

    In plain wordsIn mice with EAE, oral carnosine increased muscle carnosine levels as the dose increased.

    Peptide
    L-carnosine
    Outcome
    IncreaseMuscle carnosine levels
    Study

    mousen: not reported in source

    Chronic experimental autoimmune encephalomyelitis
    Outcome group
    Pharmacokinetics · Musculoskeletal
    Studied dose
    3, 15 or 30 g/L in drinking water · oralAs given in this study (mouse).

    Measurements

    Muscle carnosine increase
    ≤ 94%
    after 56 days EAE

    Source sentences

    Summary
    However, carnosine levels were unaltered during all stages of EAE, and even though oral carnosine supplementation dose-dependently increased muscle carnosine levels up to + 94% after 56 days EAE, this did not improve muscle function of EAE mice.
    1 context sentence
    Summary · context
    We performed muscle immunohistochemistry and ex vivo contractility measurements to examine muscle structure and function at different stages of EAE, and following nutritional intervention (oral carnosine: 3, 15 or 30 g/L in drinking water).
  2. 02LabEx vivo tissueEfficacy outcome

    In muscle from EAE mice given oral carnosine, ex vivo measurements showed no improvement in muscle function.

    In plain wordsIn lab tests, muscle from EAE mice given oral carnosine showed no improvement in muscle function.

    Peptide
    L-carnosine
    Outcome
    No significant changeMuscle function
    Study

    mousen: not reported in source

    Chronic experimental autoimmune encephalomyelitis
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    3, 15 or 30 g/L in drinking water · oralAs given in this study (mouse).

    Source sentences

    Summary
    However, carnosine levels were unaltered during all stages of EAE, and even though oral carnosine supplementation dose-dependently increased muscle carnosine levels up to + 94% after 56 days EAE, this did not improve muscle function of EAE mice.
    1 context sentence
    Summary · context
    We performed muscle immunohistochemistry and ex vivo contractility measurements to examine muscle structure and function at different stages of EAE, and following nutritional intervention (oral carnosine: 3, 15 or 30 g/L in drinking water).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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