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Study · Animal study (in vivo) · rat · 2022

8 results

Exogenous Nicotinamide Adenine Dinucleotide Attenuates Postresuscitation Myocardial and Neurologic Dysfunction in a Rat Model of Cardiac Arrest.

Su C, Xiao Y, Zhang G, Liang L, Li H, Cheng C, Jin T, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W

Critical care medicine1 Feb 2022Cited by 7 (Europe PMC)

PMID34637412 (opens in a new tab)DOI10.1097/ccm.0000000000005268 (opens in a new tab)PepBankPUB-34637412
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after resuscitation, NAD+ increased mean arterial pressure compared with controls at one hour.

    In plain wordsIn rats after resuscitation, NAD+ increased mean arterial pressure compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseMean arterial pressure
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    The results demonstrated that nicotinamide adenine dinucleotide+ treatment improved mean arterial pressure (at 1 hr following return of spontaneous circulation, 94.69 ± 4.25 mm Hg vs 89.57 ± 7.71 mm Hg; p < 0.05)
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after resuscitation, NAD+ increased ejection fraction compared with controls.

    In plain wordsIn rats after resuscitation, NAD+ increased ejection fraction compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseEjection fraction
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    ejection fraction (at 1 hr following return of spontaneous circulation, 62.67% ± 6.71% vs 52.96% ± 9.37%; p < 0.05)
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after resuscitation, NAD+ improved Neurologic Deficit Score compared with controls.

    In plain wordsIn rats after resuscitation, NAD+ improved the neurological score compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseNeurologic Deficit Score
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    Neurologic Deficit Score (at 24 hr following return of spontaneous circulation, 449.50 ± 82.58 vs 339.50 ± 90.66; p < 0.05)
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after resuscitation, NAD+ increased survival rate compared with controls.

    In plain wordsIn rats after resuscitation, NAD+ increased survival compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSurvival rate
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Mortality · Whole body
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    and survival rate compared with that of the control group.
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats after resuscitation, NAD+ restored ATP levels compared with controls.

    In plain wordsIn rats after resuscitation, NAD+ restored ATP levels compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseATP level
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    The adenosine triphosphate level and complex I respiratory were significantly restored in the NAD group compared with those of the control group.
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats after resuscitation, NAD+ restored complex I respiration compared with controls.

    In plain wordsIn rats after resuscitation, NAD+ restored mitochondrial complex I respiration compared with controls.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseComplex I respiration
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Comparator
    Control group
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    The adenosine triphosphate level and complex I respiratory were significantly restored in the NAD group compared with those of the control group.
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats after resuscitation, NAD+ activated the Sirtuin3 pathway.

    In plain wordsIn rats after resuscitation, NAD+ activated the Sirtuin3 pathway.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSirtuin3 pathway activation
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    In addition, nicotinamide adenine dinucleotide+ treatment activated the Sirtuin3 pathway, down-regulating acetylated-NDUFA9 in the isolated mitochondria protein.
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats after resuscitation, NAD+ reduced acetylated NDUFA9 in isolated mitochondrial protein.

    In plain wordsIn rats after resuscitation, NAD+ reduced acetylated NDUFA9 in mitochondria.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseAcetylated NDUFA9
    Study

    ratn: not reported in source

    Sprague-Dawley rat cardiac arrest model
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    20 mg/kg · IVAs given in this study (rat).

    Source sentences

    Summary
    In addition, nicotinamide adenine dinucleotide+ treatment activated the Sirtuin3 pathway, down-regulating acetylated-NDUFA9 in the isolated mitochondria protein.
    3 context sentences
    Summary · context
    Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups.
    Summary · context
    Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation.
    Summary · context
    Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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