Skip to content

Study · Animal study (in vivo) · c. elegans and mouse · 2022

4 results

Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

Kim SJ, Devgan A, Miller B, Lee SM, Kumagai H, Wilson KA, Wassef G, Wong R, Mehta HH, Cohen P, Yen K

Biochimica et biophysica acta. General subjects6 Oct 2021Cited by 28 (Europe PMC)

PMID34624450 (opens in a new tab)PMCIDPMC8595716 (opens in a new tab)DOI10.1016/j.bbagen.2021.130017 (opens in a new tab)PepBankPUB-34624450
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, humanin administration increased the expression of autophagy-related genes in skeletal muscle.

    In plain wordsIn mice, humanin raised the activity of recycling-related genes in skeletal muscle.

    Peptide
    Humanin
    Outcome
    IncreaseExpression of autophagy-related genes in skeletal muscle
    Study

    mousen: not reported in source

    Mouse skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin administration increases the expression of autophagy-related genes and lowers accumulation of harmful misfolded proteins in mice skeletal muscle
    1 context sentence
    Summary · context
    We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, humanin administration lowered the accumulation of harmful misfolded proteins in skeletal muscle.

    In plain wordsIn mice, humanin lowered the build-up of damaged proteins in skeletal muscle.

    Peptide
    Humanin
    Outcome
    DecreaseAccumulation of misfolded proteins in skeletal muscle
    Study

    mousen: not reported in source

    Mouse skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin administration increases the expression of autophagy-related genes and lowers accumulation of harmful misfolded proteins in mice skeletal muscle
    1 context sentence
    Summary · context
    We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In C. elegans, autophagy was critical for humanin-induced lifespan extension.

    In plain wordsIn C. elegans worms, humanin extended lifespan, and this depended on autophagy.

    Peptide
    Humanin
    Outcome
    IncreaseAutophagy dependence of humanin-induced lifespan extension
    Study

    C. elegansn: not reported in source

    C. elegans
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, autophagy is a critical role in humanin-induced lifespan extension in C. elegans.
    1 context sentence
    Summary · context
    We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.
  4. 04LabIn vitro (cells)Mechanism

    In several cell types, humanin increased autophagy and maintained autophagy flux.

    In plain wordsIn lab tests on several cell types, humanin increased autophagy, the cell's recycling process.

    Peptide
    Humanin
    Outcome
    IncreaseAutophagy and autophagy flux
    Study

    n: not reported in source

    Several cell types
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin, a mitochondrial-derived peptide, increases autophagy and maintains autophagy flux in several cell types.
    1 context sentence
    Summary · context
    We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.