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Study · Animal study (in vivo) · rat · 2021

11 results

Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats.

Wan Y, He B, Zhu D, Wang L, Huang R, Zhu J, Wang C, Gao F

Archives of biochemistry and biophysics2 Oct 2021Cited by 29 (Europe PMC)

PMID34610336 (opens in a new tab)DOI10.1016/j.abb.2021.109050 (opens in a new tab)PepBankPUB-34610336
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN alleviated cardiac dysfunction.

    In plain wordsIn rats, NMN reduced cardiac dysfunction compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCardiac dysfunction
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results of the present study showed that DOX treatment significantly induced cardiac dysfunction and cardiac injury, whereas NMN alleviated these changes.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN alleviated cardiac injury.

    In plain wordsIn rats, NMN reduced cardiac injury compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCardiac injury
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results of the present study showed that DOX treatment significantly induced cardiac dysfunction and cardiac injury, whereas NMN alleviated these changes.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN inhibited NLRP3 inflammasome-mediated inflammation.

    In plain wordsIn rats, NMN reduced NLRP3 inflammasome-mediated inflammation compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseNLRP3 inflammasome-mediated inflammation
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN decreased caspase 1 activity.

    In plain wordsIn rats, NMN reduced caspase 1 activity compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCaspase 1 activity
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN decreased IL-1β activity.

    In plain wordsIn rats, NMN reduced IL-1β activity compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIL-1β activity
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN increased glutathione levels.

    In plain wordsIn rats, NMN increased glutathione levels compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGlutathione levels
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN increased superoxide dismutase activity.

    In plain wordsIn rats, NMN increased superoxide dismutase activity compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN decreased malondialdehyde levels.

    In plain wordsIn rats, NMN reduced malondialdehyde levels compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMalondialdehyde levels
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN decreased reactive oxygen species levels.

    In plain wordsIn rats, NMN reduced reactive oxygen species compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive oxygen species levels
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN mitigated cardiomyocyte apoptosis.

    In plain wordsIn rats, NMN reduced heart cell death compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCardiomyocyte apoptosis
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated DOX-induced cardiomyocyte apoptosis and cardiac fibrosis.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to doxorubicin, NMN mitigated cardiac fibrosis.

    In plain wordsIn rats, NMN reduced cardiac fibrosis compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCardiac fibrosis
    Study

    ratn: not reported in source

    Doxorubicin-induced cardiotoxicity
    Comparator
    Doxorubicin without NMN
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated DOX-induced cardiomyocyte apoptosis and cardiac fibrosis.
    1 context sentence
    Summary · context
    Here, we aimed to investigate the effect of nicotinamide mononucleotide (NMN) on DIC in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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