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Study · Animal study (in vivo) · rat · 2022

2 results

Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.

Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A

Molecular and cellular endocrinology1 Oct 2021Cited by 21 (Europe PMC)

PMID34606964 (opens in a new tab)DOI10.1016/j.mce.2021.111472 (opens in a new tab)PepBankPUB-34606964
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In SDT fatty rats with type 2 diabetes, liraglutide increased citrate synthase activity in the soleus muscle, independently of blood glucose and blood pressure.

    In plain wordsIn rats with type 2 diabetes, liraglutide raised a marker of mitochondrial content in a leg muscle.

    Peptide
    Liraglutide
    Outcome
    IncreaseCitrate synthase activity in soleus muscle
    Study

    ratn: not reported in source

    Spontaneously diabetic Torii (SDT) fatty rats
    Comparator
    Vehicle-treated SDT fatty rats
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the soleus of SDT fatty rats, liraglutide led to greater citrate synthase activity and cytochrome c oxidase subunit 5 B protein expression, independently of blood glucose and blood pressure levels.
    1 context sentence
    Summary · context
    Male SDT fatty rats (8-week-old) were provided liraglutide, or insulin-hydralazine for 8 weeks; control SDT fatty rats and SD rats were administered a vehicle.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In SDT fatty rats with type 2 diabetes, liraglutide increased cytochrome c oxidase subunit 5 B protein expression in the soleus muscle, independently of blood glucose and blood pressure.

    In plain wordsIn rats with type 2 diabetes, liraglutide raised a mitochondrial protein in a leg muscle.

    Peptide
    Liraglutide
    Outcome
    IncreaseCytochrome c oxidase subunit 5B protein expression in soleus muscle
    Study

    ratn: not reported in source

    Spontaneously diabetic Torii (SDT) fatty rats
    Comparator
    Vehicle-treated SDT fatty rats
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the soleus of SDT fatty rats, liraglutide led to greater citrate synthase activity and cytochrome c oxidase subunit 5 B protein expression, independently of blood glucose and blood pressure levels.
    1 context sentence
    Summary · context
    Male SDT fatty rats (8-week-old) were provided liraglutide, or insulin-hydralazine for 8 weeks; control SDT fatty rats and SD rats were administered a vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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