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Study · Animal study (in vivo) · honeybee (apis mellifera) · 2021

2 results

Physiological and Immunological Status of Adult Honeybees (Apis mellifera) Fed Sugar Syrup Supplemented with Pentadecapeptide BPC 157.

Tlak Gajger I, Smodiš Škerl MI, Šoštarić P, Šuran J, Sikirić P, Vlainić J

Biology9 Sept 2021Cited by 21 (Europe PMC)

PMID34571768 (opens in a new tab)PMCIDPMC8467873 (opens in a new tab)DOI10.3390/biology10090891 (opens in a new tab)PepBankPUB-34571768
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Summary

Various factors contribute to a decline in diversity and number of bees. Here, an integrated approach in experimental BPC 157 therapy was implemented, combining laboratory-controlled and field study results. The aim of a study was to assess the effects of BPC 157 additional feeding of newly emerged worker honeybees on few biochemical and immunological parameters in hemolymph (glucose, trehalose, lipids, proteins, vitellogenin, glucose-oxidase (GOX)), and hypopharyngeal gland (HPG), in laboratory-controlled conditions. Additionally, to examine the physiological status of protein digestion, the enzymatic activity of leucine aminopeptidase (LAP) in the mid-guts of worker honeybees was analyzed. It was found that individual honeybees, in hoarding cages, following BPC 157 administration through carbohydrate food, showed positive physiological changes when compared to the control groups. Those results were complemented by strong and visible LAP activity, particularly noticeable in the apical parts of the epithelial cells in the mid-guts of young worker honeybees originated from treated hives, suggesting a link between alternative oral therapy with BPC 157 and honeybees' immunity.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In worker honeybees in hoarding cages, BPC‑157 given in carbohydrate food produced positive physiological changes compared with control groups.

    In plain wordsIn honeybees, BPC‑157 in food led to positive physiological changes compared with control bees.

    Peptide
    BPC-157
    Outcome
    Direction not reportedPhysiological and immunological parameters in hemolymph
    Study

    honeybee (Apis mellifera)n: not reported in source

    Hoarding cages, laboratory-controlled
    Comparator
    Control groups
    Outcome group
    Immune response · Whole body
    Studied dose
    Dose not stated · oral, in carbohydrate foodAs given in this study (honeybee (Apis mellifera)).

    Source sentences

    Summary
    It was found that individual honeybees, in hoarding cages, following BPC 157 administration through carbohydrate food, showed positive physiological changes when compared to the control groups.
    1 context sentence
    Summary · context
    The aim of a study was to assess the effects of BPC 157 additional feeding of newly emerged worker honeybees on few biochemical and immunological parameters in hemolymph (glucose, trehalose, lipids, proteins, vitellogenin, glucose-oxidase (GOX)), and hypopharyngeal gland (HPG), in laboratory-controlled conditions.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In young worker honeybees from hives treated with BPC‑157, leucine aminopeptidase activity in mid-gut epithelial cells was strong and visible.

    In plain wordsIn honeybees from treated hives, a digestive enzyme showed strong activity in the gut lining.

    Peptide
    BPC-157
    Outcome
    Direction not reportedLeucine aminopeptidase activity in the mid-gut
    Study

    honeybee (Apis mellifera)n: not reported in source

    Hives treated with BPC 157
    Outcome group
    Immune response · Whole body
    Studied dose
    Dose not stated · oral, in carbohydrate foodAs given in this study (honeybee (Apis mellifera)).

    Source sentences

    Summary
    Those results were complemented by strong and visible LAP activity, particularly noticeable in the apical parts of the epithelial cells in the mid-guts of young worker honeybees originated from treated hives
    1 context sentence
    Summary · context
    The aim of a study was to assess the effects of BPC 157 additional feeding of newly emerged worker honeybees on few biochemical and immunological parameters in hemolymph (glucose, trehalose, lipids, proteins, vitellogenin, glucose-oxidase (GOX)), and hypopharyngeal gland (HPG), in laboratory-controlled conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Versions 2 to 3

    9 Oct 2026, 03:03 UTC

    The same notice was added 2 times, first on 9 Oct 2026, 02:59 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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