Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.

Sun L, Wei Y, Wang J

Bioengineered1 Dec 2021Cited by 8 (Europe PMC)

PMID34546850PMCIDPMC8806837DOI10.1080/21655979.2021.1978618PepBankPUB-34546850

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelIn vitro (cells)Mechanism
In endometriosis cells, circPIP5K1A regulated TMSB4X level through interaction with miR-153-3p.
In plain wordsIn cells, a circular RNA changed the cells' own TMSB4X level through a microRNA.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedTMSB4X level regulated by circPIP5K1A via miR-153-3p
Study
n: not reported in source
Endometriosis cells (hEM15A)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Also, we found that circPIP5K1A regulated TMSB4X level via interaction with miR-153-3p in EM cells.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3454685001

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In endometriosis cells, circPIP5K1A promoted endometriosis progression via TMSB4X.
In plain wordsIn cells, a circular RNA promoted endometriosis progression through TMSB4X.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableEndometriosis progression via TMSB4X
Study
n: not reported in source
Endometriosis cells (hEM15A)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Besides, circPIP5K1A promoted EM progression via TMSB4X.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3454685002
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In hEM15A cells, TMSB4X activated TGF-β signaling.
In plain wordsIn cells, TMSB4X switched on TGF-β signaling.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTGF-β signaling activation by TMSB4X
Study
n: not reported in source
Endometriosis cells (hEM15A)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Moreover, TMSB4X could activate the TGF-β signaling in hEM15A cells.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3454685003

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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