Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren.

Philip M, Karakka Kal AK, Subhahar MB, Perwad Z, Karatt TK

Rapid communications in mass spectrometry : RCM1 Dec 2021Cited by 6 (Europe PMC)

PMID34542924DOI10.1002/rcm.9201PepBankPUB-34542924

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers detected 32 ibutamoren metabolites, including 20 phase I and 12 phase II metabolites.
In plain wordsIn lab tests with horse liver microsomes, researchers detected 32 ibutamoren metabolites.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableMetabolites detected
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
A total of 32 metabolites for ibutamoren (20 phase I and 12 phase II) were detected.
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292401
02LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, ibutamoren underwent oxidation to hydroxylated metabolites.
In plain wordsIn lab tests with horse liver microsomes, ibutamoren oxidation produced hydroxylated metabolites.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableOxidation
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(1) the growth hormone secretagogue ibutamoren was prone to oxidation, resulting in corresponding hydroxylated metabolites;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292402
03LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers observed dissociation of the ibutamoren phenyl ring.
In plain wordsIn lab tests with horse liver microsomes, researchers observed detachment of ibutamoren's phenyl ring.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicablePhenyl ring dissociation
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(2) in ibutamoren, the dissociation of the phenyl ring and 2-amino-2-methylpropanamide side chain was also observed;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292403
04LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers observed dissociation of ibutamoren's 2-amino-2-methylpropanamide side chain.
In plain wordsIn lab tests with horse liver microsomes, researchers observed detachment of an ibutamoren side chain.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableSide-chain dissociation
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(2) in ibutamoren, the dissociation of the phenyl ring and 2-amino-2-methylpropanamide side chain was also observed;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292404
05LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers detected glucuronic acid conjugates of monohydroxylated ibutamoren analogues.
In plain wordsIn lab tests with horse liver microsomes, researchers detected glucuronides of monohydroxylated ibutamoren.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableMonohydroxylated glucuronide
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(3) the glucuronic acid conjugates of mono-, di- and trihydroxylated analogues were detected;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292405
06LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers detected glucuronic acid conjugates of dihydroxylated ibutamoren analogues.
In plain wordsIn lab tests with horse liver microsomes, researchers detected glucuronides of dihydroxylated ibutamoren.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableDihydroxylated glucuronide
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(3) the glucuronic acid conjugates of mono-, di- and trihydroxylated analogues were detected;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292406
07LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers detected glucuronic acid conjugates of trihydroxylated ibutamoren analogues.
In plain wordsIn lab tests with horse liver microsomes, researchers detected glucuronides of trihydroxylated ibutamoren.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableTrihydroxylated glucuronide
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(3) the glucuronic acid conjugates of mono-, di- and trihydroxylated analogues were detected;
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292407
08LabIn vitro (cell-free)Pharmacokinetics
In equine liver microsomes, researchers observed no sulfonic acid conjugated ibutamoren metabolites.
In plain wordsIn lab tests with horse liver microsomes, researchers found no ibutamoren sulfonic acid conjugates.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableSulfonic acid conjugates
Study
horsen: not reported in source
equine liver microsomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
(4) no sulfonic acid conjugated metabolites were observed in this study of ibutamoren.
1 context sentence(design, population, supporting numbers)
Summary · context
This paper describes the metabolic conversion of ibutamoren using equine liver microsomes and metabolite characterization using a QExactive high-resolution mass spectrometer.
Report a problemFND-3454292408

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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