Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Cai H, Cao P, Sun W, Shao W, Li R, Wang L, Zou L, Forno E, Muzumdar R, Gong Z, Zheng Y

Biochimica et biophysica acta. General subjects12 Sept 2021Cited by 16 (Europe PMC)

PMID34525397DOI10.1016/j.bbagen.2021.130010PepBankPUB-34525397

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with unstable angina, circulating humanin levels were lower than in controls.
In plain wordsPeople with unstable angina had lower levels of the body's own humanin than controls.
Peptide
Humanin
Outcome
DecreaseCirculating humanin in angina versus controls
Study
n: not reported in source
Comparator
Controls
Outcome group
Aging markers · Cardiovascular
Measurements
Humanin
124.22 pg/ml
angina group
Humanin
157.77 pg/ml
controls
Source sentences
Summary
Circulating humanin levels were lower in the angina group compared to controls [124.22 ± 63.02 vs. 157.77 ± 99.93 pg/ml, p < 0.05]
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography.
Summary · context
Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3452539701
02HumanEndogenous levelObservational studyOther
In patients with myocardial infarction, circulating humanin levels were lower than in controls and lower than in angina.
In plain wordsPeople with a heart attack had lower levels of the body's own humanin than controls.
Peptide
Humanin
Outcome
DecreaseCirculating humanin in myocardial infarction versus controls
Study
n: not reported in source
Comparator
Controls
Outcome group
Aging markers · Cardiovascular
Measurements
Humanin
67.17 pg/ml
MI group
Source sentences
Summary
and even lower in MI patients [67.17 ± 24.35 pg/ml, p < 0.05 vs controls]
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography.
Summary · context
Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3452539702
03HumanEndogenous levelObservational studyOther
In patients with coronary artery disease, lower circulating humanin levels were an independent risk factor for myocardial infarction.
In plain wordsLower levels of the body's own humanin were linked to a higher risk of heart attack in people with heart disease.
Peptide
Humanin
Outcome
Not applicableLower circulating humanin as risk factor for MI
Study
n: not reported in source
Outcome group
Aging markers · Cardiovascular
Source sentences
Summary
Lower circulating humanin levels was an independent risk factor of MI patients.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography.
Summary · context
Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3452539703
04HumanEndogenous levelObservational studyOther
In patients with unstable angina, circulating humanin levels could be used to predict major adverse cardiac events.
In plain wordsIn people with angina, levels of the body's own humanin could help predict major heart events.
Peptide
Humanin
Outcome
Not applicableCirculating humanin as predictor of MACE in angina group
Study
n: not reported in source
Outcome group
Aging markers · Cardiovascular
Source sentences
Summary
Circulating humanin levels could be used to predict MACE in angina group.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography.
Summary · context
Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3452539704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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