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Study · Animal study (in vivo) · mouse · 2021

8 results

The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.

Chen X, Yun C, Zheng H, Chen X, Han Q, Pan H, Wang Y, Zhong J

Bioengineered1 Dec 2021Cited by 14 (Europe PMC)

PMID34506248 (opens in a new tab)PMCIDPMC8806847 (opens in a new tab)DOI10.1080/21655979.2021.1964894 (opens in a new tab)PepBankPUB-34506248
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Summary

Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in a variety of cells and tissues. However, the pharmacological function of HNG in diabetic cardiomyopathy has not yet been reported. In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice. Myocardial hypertrophy in diabetic mice was determined using Wheat Gem Agglutinin (WGA) staining. The heart function was measured with Echocardiographic imaging. Levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) proteins in plasma were measured using enzyme-linked immunosorbent assay (ELISA) kits. Protein expression of Phosphorylated p38/p38 was determined using western blots. We found that HNG treatment attenuated the STZ-induced myocardial hypertrophy and significantly improved heart function. Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury. Lastly, HNG suppressed the activation of the p38/nuclear factor kappa-B (NF-κB) signaling pathway. S14G humanin possesses protective effects against streptozotocin-induced cardiac dysfunction through inhibiting the activation of the p38/NF-κB signaling pathway.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment attenuated myocardial hypertrophy.

    In plain wordsIn mice with diabetes, HNG reduced heart muscle thickening.

    Peptide
    Humanin
    Outcome
    DecreaseMyocardial hypertrophy
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that HNG treatment attenuated the STZ-induced myocardial hypertrophy and significantly improved heart function.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment significantly improved heart function.

    In plain wordsIn mice with diabetes, HNG improved heart function.

    Peptide
    Humanin
    Outcome
    IncreaseHeart function by echocardiography
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that HNG treatment attenuated the STZ-induced myocardial hypertrophy and significantly improved heart function.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment reduced the myocardial injury indicator CK-MB.

    In plain wordsIn mice with diabetes, HNG lowered a blood marker of heart muscle injury (CK-MB).

    Peptide
    Humanin
    Outcome
    DecreaseCreatine kinase-MB level
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment reduced the myocardial injury indicator AST.

    In plain wordsIn mice with diabetes, HNG lowered a blood marker of heart muscle injury (AST).

    Peptide
    Humanin
    Outcome
    DecreaseAspartate aminotransferase level
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment reduced the myocardial injury indicator LDH.

    In plain wordsIn mice with diabetes, HNG lowered a blood marker of heart muscle injury (LDH).

    Peptide
    Humanin
    Outcome
    DecreaseLactate dehydrogenase level
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment reduced cardiac and plasma levels of TNF-α.

    In plain wordsIn mice with diabetes, HNG lowered the inflammatory signal TNF-α in heart and blood.

    Peptide
    Humanin
    Outcome
    DecreaseCardiac and plasma TNF-α
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, HNG treatment reduced cardiac and plasma levels of IL-6.

    In plain wordsIn mice with diabetes, HNG lowered the inflammatory signal IL-6 in heart and blood.

    Peptide
    Humanin
    Outcome
    DecreaseCardiac and plasma IL-6
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and both the cardiac and plasma levels of TNF-α and IL-6, highlighting its effect on the STZ-induced myocardial injury.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In STZ-induced diabetic mice, HNG suppressed activation of the p38/NF-κB signaling pathway.

    In plain wordsIn mice with diabetes, HNG reduced activity of an inflammation pathway (p38/NF-κB).

    Peptide
    Humanin
    Outcome
    Decreasep38/NF-κB pathway activation
    Study

    micen: not reported in source

    Streptozotocin-induced diabetic mice
    Comparator
    STZ-treated mice without HNG
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Lastly, HNG suppressed the activation of the p38/nuclear factor kappa-B (NF-κB) signaling pathway.
    1 context sentence
    Summary · context
    In the present study, we investigated the protective effects of HNG against streptozotocin (STZ)-induced cardiac dysfunction in diabetic mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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