In muscle biopsies from patients with myositis, a network module of nuclear isoforms of the anti-apoptotic humanin protein was suppressed compared with normal controls.
In plain wordsIn people with myositis, activity of the body's own humanin gene variants in muscle was lower than in healthy controls.
- Peptide
- Humanin
- Outcome
- DecreaseExpression of nuclear humanin isoform module in myositis muscle
- Study
n = 139
Muscle biopsy transcriptome- Comparator
- Normal controls
- Outcome group
- Inflammation markers · Musculoskeletal
Source sentences
Universally myositis-suppressed pathways included a specific subset of myofilaments, the mitochondrial envelope, and nuclear isoforms of the anti-apoptotic humanin protein.
1 context sentence(design, population, supporting numbers)
Using muscle biopsy transcriptome profiles from 119 myositis patients (spanning major clinical and serological disease subtypes) and 20 normal controls, we generated a co-expression network of 8101 dynamically regulated transcripts.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.