Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide.

Xia X, Xue S, Yang G, Li Y, Liu H, Chen C, Li L

PeerJ20 Aug 2021Cited by 8 (Europe PMC)

PMID34484983PMCIDPMC8381879DOI10.7717/peerj.11869PepBankPUB-34484983

Summary

Background and aimsFetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR.MethodsA total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA.ResultsIn IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women.Conclusionsserum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

01HumanNon-randomized trialEfficacy outcome
In young overweight or obese women with impaired glucose tolerance, serum fetuin-B fell significantly after 24 weeks of liraglutide.
In plain wordsIn young women with impaired glucose tolerance, blood fetuin-B levels fell after liraglutide treatment.
Peptide
Liraglutide
Outcome
DecreaseSerum fetuin-B after liraglutide treatment
Study
n: not reported in source
Outcome group
Adipokines · Metabolic and weight
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Source sentences
Summary
After Lira intervention, serum fetuin-B decreased significantly in IGT women.
1 context sentence(design, population, supporting numbers)
Summary · context
A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA.
Show in the study text Report a problemFND-3448498301

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Version history

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Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 03:05 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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