In rats with chronic brain ischemia, Cerebrolysin increased brain lactate content compared with control.
In plain wordsIn rats with chronic brain ischemia, Cerebrolysin increased brain lactate compared with control.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseLactate content
- Study
ratsn: not reported in source
Chronic brain ischemia- Comparator
- Control group
- Outcome group
- Mitochondrial function · Nervous system and cognition
- Studied dose
- 7.5 ml/kg/day · 2 ten-day courses of therapy, separated by a break of 10 daysAs given in this study (rats).
Source sentences
Compared with the control group, in the groups that received cortexin at a dose of 3 mg/kg/day, cerebrolysin at a dose of 7.5 ml/kg/day and actovegin at a dose of 5 ml/kg/day, there were an increase in the content of lactate and pyruvate (without a significant change in their ratio)
2 context sentences(design, population, supporting numbers)
Chronic brain ischemia was modeled in male rats by 50% stenosis of the common carotid arteries.
Forty days after surgery, the animals received 2 ten-day courses of therapy, separated by a break of 10 days.