S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.

Shi D, Zhou X, Wang H

Inflammation research : official journal of the European Histamine Research Society ... [et al.]30 Aug 2021Cited by 11 (Europe PMC)

PMID34459932DOI10.1007/s00011-021-01489-4PepBankPUB-34459932

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In UV-B-challenged HRECs, HNG treatment inhibited activation of the TXNIP/NLRP3 signaling pathway.
In plain wordsIn cells, HNG reduced activation of an inflammation pathway (TXNIP/NLRP3) triggered by UV-B light.
Peptide
Humanin
Outcome
DecreaseTXNIP/NLRP3 pathway activation after UV-B
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
UV-B without HNG
Outcome group
Inflammation markers · Eye
Studied dose
Dose not stated
Source sentences
Summary
treatment with HNG inhibited the activation of the TXNIP/NLRP3 signaling pathway
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
Report a problemFND-3445993201
02LabIn vitro (cells)Mechanism
In UV-B-challenged HRECs, HNG treatment mitigated the excessive release of IL-1β.
In plain wordsIn cells, HNG reduced the release of the inflammatory signal IL-1β caused by UV-B light.
Peptide
Humanin
Outcome
DecreaseIL-1β release after UV-B
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
UV-B without HNG
Outcome group
Inflammation markers · Eye
Studied dose
Dose not stated
Source sentences
Summary
treatment with HNG inhibited the activation of the TXNIP/NLRP3 signaling pathway and mitigated the excessive release of IL-1β and IL-18 in UV-B-challenged HRECs.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
Report a problemFND-3445993202
03LabIn vitro (cells)Mechanism
In UV-B-challenged HRECs, HNG treatment mitigated the excessive release of IL-18.
In plain wordsIn cells, HNG reduced the release of the inflammatory signal IL-18 caused by UV-B light.
Peptide
Humanin
Outcome
DecreaseIL-18 release after UV-B
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
UV-B without HNG
Outcome group
Inflammation markers · Eye
Studied dose
Dose not stated
Source sentences
Summary
treatment with HNG inhibited the activation of the TXNIP/NLRP3 signaling pathway and mitigated the excessive release of IL-1β and IL-18 in UV-B-challenged HRECs.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
Report a problemFND-3445993203
04LabIn vitro (cells)Mechanism
In HRECs, HNG treatment attenuated the UV-B-induced expression of Egr-1.
In plain wordsIn cells, HNG lowered the UV-B-driven rise of the protein Egr-1.
Peptide
Humanin
Outcome
DecreaseEgr-1 expression after UV-B
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
UV-B without HNG
Outcome group
Inflammation markers · Eye
Studied dose
Dose not stated
Source sentences
Summary
treatment with HNG attenuated UV-B-induced expression of Egr-1.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
Report a problemFND-3445993204

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

05LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HRECs, Egr-1 overexpression abolished the inhibitory effect of HNG on NLRP3 activation.
In plain wordsIn cells, raising Egr-1 removed the effect of HNG that blocked NLRP3 activation.
Peptide
Humanin
Outcome
IncreaseHNG inhibition of NLRP3 activation with Egr-1 overexpression
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
HNG without Egr-1 overexpression
Outcome group
Inflammation markers · Eye
Source sentences
Summary
However, overexpression of Egr-1 abolished the inhibitory effects of HNG-induced activation of NLRP3 as well as the production of IL-1β and IL-18.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3445993205
06LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HRECs, Egr-1 overexpression abolished the inhibitory effect of HNG on IL-1β production.
In plain wordsIn cells, raising Egr-1 removed the effect of HNG that lowered IL-1β production.
Peptide
Humanin
Outcome
IncreaseHNG inhibition of IL-1β production with Egr-1 overexpression
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
HNG without Egr-1 overexpression
Outcome group
Inflammation markers · Eye
Source sentences
Summary
However, overexpression of Egr-1 abolished the inhibitory effects of HNG-induced activation of NLRP3 as well as the production of IL-1β and IL-18.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3445993206
07LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HRECs, Egr-1 overexpression abolished the inhibitory effect of HNG on IL-18 production.
In plain wordsIn cells, raising Egr-1 removed the effect of HNG that lowered IL-18 production.
Peptide
Humanin
Outcome
IncreaseHNG inhibition of IL-18 production with Egr-1 overexpression
Study
humann: not reported in source
Human retinal endothelial cells (HRECs)
Comparator
HNG without Egr-1 overexpression
Outcome group
Inflammation markers · Eye
Source sentences
Summary
However, overexpression of Egr-1 abolished the inhibitory effects of HNG-induced activation of NLRP3 as well as the production of IL-1β and IL-18.
1 context sentence(design, population, supporting numbers)
Summary · context
UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs).
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3445993207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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