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Study · Animal study (in vivo) · rat · 2022

5 results

Endogenous dipeptide-carnosine supplementation ameliorates hypobaric hypoxia-induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis.

Agrawal A, Rathor R, Kumar R, Singh SN, Kumar B, Suryakumar G

IUBMB life29 Aug 2021Cited by 10 (Europe PMC)

PMID34455667 (opens in a new tab)DOI10.1002/iub.2539 (opens in a new tab)PepBankPUB-34455667
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxia-exposed rats, carnosine ameliorated oxidative protein damage.

    In plain wordsIn rats exposed to hypoxia, carnosine reduced oxidative protein damage compared with hypoxia exposure alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseOxidative protein damage
    Study

    ratn: not reported in source

    Hypobaric hypoxia-exposed male Sprague-Dawley rats
    Comparator
    HH-exposed group
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    150 mg/kg b.w · oral · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    HH-exposed rats supplemented with CAR ameliorated HH-induced oxidative protein damage, lipid peroxidation, and maintained pro-inflammatory cytokines levels.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats (n = 5) were randomly divided into control group, HH-exposed group (3 days HH exposure equivalent to 7,620 m), and HH-exposed rats supplemented with carnosine (3 days; 150 mg/kg b.w, orally) (HH + CAR).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxia-exposed rats, carnosine ameliorated lipid peroxidation.

    In plain wordsIn rats exposed to hypoxia, carnosine reduced lipid peroxidation compared with hypoxia exposure alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseLipid peroxidation
    Study

    ratn: not reported in source

    Hypobaric hypoxia-exposed male Sprague-Dawley rats
    Comparator
    HH-exposed group
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    150 mg/kg b.w · oral · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    HH-exposed rats supplemented with CAR ameliorated HH-induced oxidative protein damage, lipid peroxidation, and maintained pro-inflammatory cytokines levels.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats (n = 5) were randomly divided into control group, HH-exposed group (3 days HH exposure equivalent to 7,620 m), and HH-exposed rats supplemented with carnosine (3 days; 150 mg/kg b.w, orally) (HH + CAR).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hypoxia-exposed rats, carnosine maintained pro-inflammatory cytokine levels.

    In plain wordsIn rats exposed to hypoxia, carnosine maintained pro-inflammatory cytokine levels compared with hypoxia exposure alone.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedPro-inflammatory cytokines
    Study

    ratn: not reported in source

    Hypobaric hypoxia-exposed male Sprague-Dawley rats
    Comparator
    HH-exposed group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    150 mg/kg b.w · oral · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    HH-exposed rats supplemented with CAR ameliorated HH-induced oxidative protein damage, lipid peroxidation, and maintained pro-inflammatory cytokines levels.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats (n = 5) were randomly divided into control group, HH-exposed group (3 days HH exposure equivalent to 7,620 m), and HH-exposed rats supplemented with carnosine (3 days; 150 mg/kg b.w, orally) (HH + CAR).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In hypoxia-exposed rats, carnosine regulated muscle protein degradative pathways, including calpain, ubiquitination, endoplasmic reticulum stress, autophagy and apoptosis.

    In plain wordsIn rats exposed to hypoxia, carnosine regulated muscle protein degradation pathways compared with hypoxia exposure alone.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMuscle protein degradative pathways
    Study

    ratn: not reported in source

    Hypobaric hypoxia-exposed male Sprague-Dawley rats
    Comparator
    HH-exposed group
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    150 mg/kg b.w · oral · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    HH-associated muscle protein degradative pathways, including calpain, ubiquitination, endoplasmic reticulum stress, autophagy, and apoptosis were also regulated in carnosine-supplemented rats.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats (n = 5) were randomly divided into control group, HH-exposed group (3 days HH exposure equivalent to 7,620 m), and HH-exposed rats supplemented with carnosine (3 days; 150 mg/kg b.w, orally) (HH + CAR).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxia-exposed rats, carnosine reduced serum creatine phosphokinase levels.

    In plain wordsIn rats exposed to hypoxia, carnosine reduced the muscle damage marker creatine phosphokinase compared with hypoxia exposure alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum creatine phosphokinase
    Study

    ratn: not reported in source

    Hypobaric hypoxia-exposed male Sprague-Dawley rats
    Comparator
    HH-exposed group
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    150 mg/kg b.w · oral · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    Further, the muscle damage marker, the levels of serum creatine phosphokinase were also reduced in HH + CAR co-supplemented rats which proved the protective efficacy of CAR against hypobaric hypoxia-induced muscle protein loss.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats (n = 5) were randomly divided into control group, HH-exposed group (3 days HH exposure equivalent to 7,620 m), and HH-exposed rats supplemented with carnosine (3 days; 150 mg/kg b.w, orally) (HH + CAR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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