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Study · Systematic review · 2022

8 results

The effectiveness and safety of liraglutide in treating overweight/obese patients with polycystic ovary syndrome: a meta-analysis.

Ge JJ, Wang DJ, Song W, Shen SM, Ge WH

Journal of endocrinological investigation29 Aug 2021Cited by 23 (Europe PMC)

PMID34455568 (opens in a new tab)DOI10.1007/s40618-021-01666-6 (opens in a new tab)PepBankPUB-34455568
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide alone gave greater weight loss than metformin.

    In plain wordsIn overweight or obese women with PCOS, liraglutide alone led to more weight loss than metformin.

    Peptide
    Liraglutide
    Outcome
    DecreaseWeight loss, liraglutide versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −2.74 NA
    liraglutide vs metformin

    Source sentences

    Summary
    liraglutide was superior to metformin only in weight loss [MD = - 2.74, 95% CI (- 4.29, - 1.18), P = 0.0006]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  2. 02HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide alone was superior to metformin only in weight loss; the abstract reports no advantage on other outcomes.

    In plain wordsIn overweight or obese women with PCOS, liraglutide alone beat metformin only on weight loss; the abstract reports no advantage on other outcomes.

    Peptide
    Liraglutide
    Outcome
    No significant changeOther outcomes, liraglutide versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Overall treatment effect · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    liraglutide was superior to metformin only in weight loss [MD = - 2.74, 95% CI (- 4.29, - 1.18), P = 0.0006]
    3 context sentences
    Summary · context
    The present results indicate that liraglutide and metformin have the similar effects in the treatment of overweight/obese PCOS patients.
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  3. 03HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide plus metformin gave greater weight loss than metformin alone.

    In plain wordsIn overweight or obese women with PCOS, liraglutide plus metformin led to more weight loss than metformin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseWeight loss, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −3.81 NA
    combination vs metformin

    Source sentences

    Summary
    weight loss [MD = - 3.81, 95% CI (- 5.16, - 2.46), P < 0.001]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  4. 04HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide plus metformin lowered BMI more than metformin alone.

    In plain wordsIn overweight or obese women with PCOS, liraglutide plus metformin lowered BMI more than metformin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseBMI, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −2.59 NA
    combination vs metformin

    Source sentences

    Summary
    BMI [MD = - 2.59, 95% CI (- 3.12, - 2.07), P < 0.001]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  5. 05HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide plus metformin reduced waist circumference more than metformin alone.

    In plain wordsIn overweight or obese women with PCOS, liraglutide plus metformin reduced waist size more than metformin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseWaist circumference, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −6.26 NA
    combination vs metformin

    Source sentences

    Summary
    waist circumference [MD = - 6.26, 95% CI (- 7.79, - 4.72), P < 0.001]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  6. 06HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide plus metformin lowered fasting blood glucose more than metformin alone.

    In plain wordsIn overweight or obese women with PCOS, liraglutide plus metformin lowered fasting blood sugar more than metformin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseFasting blood glucose, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −0.59 NA
    combination vs metformin

    Source sentences

    Summary
    fasting blood glucose [MD = - 0.59, 95% CI (- 0.74, - 0.44), P < 0.001]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  7. 07HumanSystematic reviewEfficacy outcome

    In overweight or obese women with PCOS, liraglutide plus metformin lowered fasting insulin more than metformin alone.

    In plain wordsIn overweight or obese women with PCOS, liraglutide plus metformin lowered fasting insulin more than metformin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseFasting insulin, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −1.52 NA
    combination vs metformin

    Source sentences

    Summary
    fasting insulin [MD = - 1.52, 95% CI (- 2.69, - 0.35), P = 0.01]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.
  8. 08HumanSystematic reviewSafety outcome

    In overweight or obese women with PCOS, the incidence of adverse reactions was higher with liraglutide plus metformin than with metformin alone.

    In plain wordsIn overweight or obese women with PCOS, side effects were more common with liraglutide plus metformin than with metformin alone.

    Peptide
    Liraglutide
    Outcome
    IncreaseAdverse reactions, liraglutide plus metformin versus metformin
    Study

    n: not reported in source

    Comparator
    Metformin
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Measurements

    RR
    2.91 NA
    combination vs metformin

    Source sentences

    Summary
    the incidence of adverse reactions was relatively high [RR = 2.91, 95% CI (1.55, 5.46), P = 0.00009]
    2 context sentences
    Summary · context
    Six randomized controlled trials of 127 related articles were obtained through searching.
    Summary · context
    Three articles compared liraglutide with metformin, and four articles compared liraglutide combined with metformin with metformin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 4NCT05702905

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

Peking University First Hospitaln = 759 May 2023 to est. 30 Jun 2025

PCOS (Polycystic Ovary Syndrome) · Semaglutide

Trial pageClinicalTrials.govUpdated 25 Mar 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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