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Study · Not a test of the peptide alone · 2021

1 result

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor.

Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE

Cell research27 Aug 2021Cited by 45 (Europe PMC)

PMID34453129 (opens in a new tab)PMCIDPMC8486761 (opens in a new tab)DOI10.1038/s41422-021-00557-y (opens in a new tab)PepBankPUB-34453129
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cell-free)Mechanism

    Cryo-electron microscopy structures of the human MC1R-Gs complex bound to afamelanotide, alpha-MSH and SHU9119 revealed the orthosteric binding pocket and a role of calcium in ligand binding.

    In plain wordsIn lab structure studies, the MC1R receptor was imaged bound to afamelanotide and other ligands, showing the binding pocket and a role for calcium.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableCryo-EM structure of MC1R-Gs complex bound to afamelanotide
    Study

    n: not reported in source

    Cryo-EM structures of the MC1R-Gs complex
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Here we present three cryo-electron microscopy structures of the MC1R-Gs complexes bound to endogenous hormone α-MSH, a marketed drug afamelanotide, and a synthetic agonist SHU9119. These structures reveal the orthosteric binding pocket for the conserved HFRW motif among melanocortins and the crucia…

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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