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Study · Animal study (in vivo) · mouse · 2021

4 results

Kisspeptin signaling and nNOS neurons in the VMHvl modulate lordosis behavior but not mate preference in female mice.

Bentefour Y, Bakker J

Neuropharmacology23 Aug 2021Cited by 20 (Europe PMC)

PMID34437905 (opens in a new tab)DOI10.1016/j.neuropharm.2021.108762 (opens in a new tab)PepBankPUB-34437905
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult female mice, a single Kp-10 injection into the ventrolateral ventromedial hypothalamus significantly increased lordosis.

    In plain wordsIn female mice, kisspeptin‑10 injected into one brain region increased lordosis, a female mating posture.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLordosis behavior after Kp-10 injection into VMHvl
    Study

    mousen: not reported in source

    Adult female mice with bilateral cannula aimed at the VMHvl
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · injection into the VMHvl via cannula · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    A single injection with kisspeptin (Kp-10) or SNAP/BAY, a nitric oxide donor, significantly increased lordosis
    1 context sentence
    Summary · context
    Adult female mice received a bilateral cannula aimed at the VMHvl.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult female mice, Kp-10 injected into the VMHvl did not affect mate preference.

    In plain wordsIn female mice, kisspeptin‑10 injected into one brain region did not change which male the female preferred.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeMate preference after Kp-10 injection into VMHvl
    Study

    mousen: not reported in source

    Adult female mice with bilateral cannula aimed at the VMHvl
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · injection into the VMHvl via cannula · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    None of these drugs affected mate preference.
    2 context sentences
    Summary · context
    A single injection with kisspeptin (Kp-10)
    Summary · context
    Adult female mice received a bilateral cannula aimed at the VMHvl.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult female mice, Kp-10 given directly into the paraventricular nucleus had no effect on lordosis.

    In plain wordsIn female mice, kisspeptin‑10 injected into a different brain region did not change lordosis.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLordosis after Kp-10 injection into PVN
    Study

    mousen: not reported in source

    Adult female mice with bilateral cannula aimed at the VMHvl
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · injection into the PVNAs given in this study (mouse).

    Source sentences

    Summary
    To determine whether the stimulatory effect of Kp-10 on lordosis was specific to the VMHvl, an additional group of females received Kp-10 directly into the paraventricular nucleus (PVN). No effect was found on lordosis and mate preference.
    1 context sentence
    Summary · context
    Adult female mice received a bilateral cannula aimed at the VMHvl.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult female mice, Kp-10 given directly into the paraventricular nucleus had no effect on mate preference.

    In plain wordsIn female mice, kisspeptin‑10 injected into a different brain region did not change mate preference.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeMate preference after Kp-10 injection into PVN
    Study

    mousen: not reported in source

    Adult female mice with bilateral cannula aimed at the VMHvl
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · injection into the PVNAs given in this study (mouse).

    Source sentences

    Summary
    To determine whether the stimulatory effect of Kp-10 on lordosis was specific to the VMHvl, an additional group of females received Kp-10 directly into the paraventricular nucleus (PVN). No effect was found on lordosis and mate preference.
    1 context sentence
    Summary · context
    Adult female mice received a bilateral cannula aimed at the VMHvl.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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