Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats.

Yuan C, Huang WQ, Guo JH, Liu XY, Yang JZ, Chen JJ, Wu Y, Ruan YC, Liu JY, Cui YG, Diao FY, Chan HC

Biochimica et biophysica acta. Molecular basis of disease10 Aug 2021Cited by 14 (Europe PMC)

PMID34389474DOI10.1016/j.bbadis.2021.166242PepBankPUB-34389474

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In the hypothalamus of rats with DHT-induced PCOS, Kp10 reversed or suppressed the activated unfolded protein response pathways.
In plain wordsIn rats with a PCOS-like condition, Kp10 reduced cell stress pathways in the brain.
Peptide
Kisspeptin-10
Outcome
DecreaseHypothalamic UPR pathways in PCOS rats
Study
ratn: not reported in source
DHT-induced PCOS rat model
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Kp10, the most potent peptide of kisspeptin, effectively reversed or suppressed the activated UPR pathways induced by DHT or thapsigargin, an ER stress activator, in GT1-7 cells, as well as in the hypothalamus in PCOS rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
Report a problemFND-3438947405
02LabIn vitro (cells)Mechanism
In GT1-7 cells, Kp10 reversed or suppressed the unfolded protein response pathways activated by DHT or thapsigargin.
In plain wordsIn cells, Kp10 reduced cell stress pathways switched on by DHT or thapsigargin.
Peptide
Kisspeptin-10
Outcome
DecreaseUPR pathways induced by DHT or thapsigargin
Study
n: not reported in source
GT1-7 hypothalamic neuronal cell line
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Kp10, the most potent peptide of kisspeptin, effectively reversed or suppressed the activated UPR pathways induced by DHT or thapsigargin, an ER stress activator, in GT1-7 cells, as well as in the hypothalamus in PCOS rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
Report a problemFND-3438947404
03LabIn vitro (cells)Mechanism
In GT1-7 cells, kisspeptin attenuated the thapsigargin-induced Ca2+ response.
In plain wordsIn cells, kisspeptin reduced the calcium response caused by thapsigargin.
Peptide
Kisspeptin-10
Outcome
DecreaseThapsigargin-induced Ca2+ response
Study
n: not reported in source
GT1-7 hypothalamic neuronal cell line
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Similarly, kisspeptin attenuated thapsigargin-induced Ca²⁺ response and the DHT- induced insulin resistance in GT1-7 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
Report a problemFND-3438947406
04LabIn vitro (cells)Mechanism
In GT1-7 cells, kisspeptin attenuated the DHT-induced insulin resistance.
In plain wordsIn cells, kisspeptin reduced the insulin resistance caused by DHT.
Peptide
Kisspeptin-10
Outcome
DecreaseDHT-induced insulin resistance
Study
n: not reported in source
GT1-7 hypothalamic neuronal cell line
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Similarly, kisspeptin attenuated thapsigargin-induced Ca²⁺ response and the DHT- induced insulin resistance in GT1-7 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
Report a problemFND-3438947407

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

05HumanEndogenous levelObservational studyMechanism
Plasma kisspeptin was lower in women with PCOS than in women without PCOS.
In plain wordsWomen with PCOS had lower levels of the body's own kisspeptin in blood than women without PCOS.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma kisspeptin in PCOS
Study
n: not reported in source
Comparator
Women without PCOS
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
We detected higher testosterone and lower kisspeptin levels in the plasma of PCOS than that in non-PCOS women.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3438947401
06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats with DHT-induced PCOS, hypothalamic kisspeptin expression was significantly lower than in controls.
In plain wordsIn rats with a PCOS-like condition, the body's own kisspeptin in the brain was lower than in control rats.
Peptide
Kisspeptin-10
Outcome
DecreaseHypothalamic kisspeptin expression in PCOS rats
Study
ratn: not reported in source
DHT-induced PCOS rat model
Comparator
Control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
We established a PCOS rat model by dihydrotestosterone (DHT) chronic exposure, and observed significantly downregulated kisspeptin expression and activated UPR pathways in PCOS rat hypothalamus compared to that in controls.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3438947402

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

07LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In GT1-7 hypothalamic neuronal cells, inhibiting or knocking down kisspeptin mimicked the DHT-induced enhancement of unfolded protein response pathways.
In plain wordsIn cells, blocking kisspeptin copied the effect of DHT on cell stress pathways.
Peptide
Kisspeptin-10
Outcome
IncreaseUPR pathway activation after kisspeptin inhibition or knockdown
Study
n: not reported in source
GT1-7 hypothalamic neuronal cell line
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Inhibition or knockdown of kisspeptin completely mimicked the enhancing effect of DHT on UPR pathways in a hypothalamic neuronal cell line, GT1-7.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the relationship of kisspeptin and ER stress, we detected kisspeptin and other factors in blood plasm of PCOS patients, rat models and hypothalamic neuronal cells.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3438947403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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