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Study · Not a test of the peptide alone · 2021

5 results

The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis.

Tomassetti C, Beukeleirs T, Conforti A, Debrock S, Peeraer K, Meuleman C, D'Hooghe T

Human reproduction (Oxford, England)1 Sept 2021Cited by 19 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In operated endometriosis patients, the ultra-long triptorelin protocol did not significantly change fresh-cycle fetal-heartbeat pregnancy rates versus the classical protocol.

    In plain wordsIn operated endometriosis patients, fetal-heartbeat pregnancy rates did not differ significantly between the ultra-long triptorelin and classical protocols.

    Outcome
    No significant changeClinical pregnancy with positive fetal heartbeat
    Study

    n = 40

    Comparator
    classical long agonist ART protocol
    Analysis
    Primary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    CPHB rate
    20%
    ultra-long group
    CPHB rate
    25%
    control group

    Source sentences

    Summary
    The primary outcome studied-CPHB after the initiated ART treatment-did not differ and was 25% (5/20) in the control group, and 20% (4/20) in the ultra-long group (P > 0.999; relative risk (RR) 1.25, 95% CI 0.41-3.88).
    2 context sentences
    Summary · context
    Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?
    Summary · context
    the control group underwent ART stimulation in a classical long agonist protocol using preparation with oral contraceptives, the ultra-long group first underwent at least 3 months downregulation followed by a long agonist protocol for ART stimulation.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In operated endometriosis patients, ovarian stimulation lasted longer with the ultra-long triptorelin protocol than with the classical protocol.

    In plain wordsIn operated endometriosis patients, stimulation lasted longer with the ultra-long triptorelin protocol than with the classical protocol.

    Outcome
    IncreaseOvarian stimulation duration
    Study

    n: not reported in source

    Comparator
    classical long agonist ART protocol
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Stimulation duration
    13.2 days
    ultra-long group
    Stimulation duration
    11.8 days
    control group

    Source sentences

    Summary
    When other secondary outcomes were compared with the ultra-long group, patients from the control group had a shorter duration of stimulation (mean 11.8 days (SD ± 2.4) versus 13.2 days (SD ± 1.5), P = 0.0373)
    2 context sentences
    Summary · context
    Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?
    Summary · context
    the control group underwent ART stimulation in a classical long agonist protocol using preparation with oral contraceptives, the ultra-long group first underwent at least 3 months downregulation followed by a long agonist protocol for ART stimulation.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In operated endometriosis patients, the ultra-long triptorelin protocol required more gonadotrophins than the classical protocol.

    In plain wordsIn operated endometriosis patients, the ultra-long triptorelin protocol required more gonadotrophins than the classical protocol.

    Outcome
    IncreaseTotal gonadotrophin dose
    Study

    n: not reported in source

    Comparator
    classical long agonist ART protocol
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Total gonadotrophin dose
    2329 IU/d
    ultra-long group
    Total gonadotrophin dose
    1793 IU/d
    control group

    Source sentences

    Summary
    a lower total dose of gonadotrophins used (mean 1793 IU/d (SD ± 787) vs 2329 (SD ± 680), P = 0.0154)
    2 context sentences
    Summary · context
    Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?
    Summary · context
    the control group underwent ART stimulation in a classical long agonist protocol using preparation with oral contraceptives, the ultra-long group first underwent at least 3 months downregulation followed by a long agonist protocol for ART stimulation.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  4. 04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In operated endometriosis patients, estradiol at stimulation end was lower with the ultra-long triptorelin protocol than with the classical protocol.

    In plain wordsIn operated endometriosis patients, estradiol was lower after stimulation with the ultra-long triptorelin protocol than with the classical protocol.

    Outcome
    DecreaseEstradiol at stimulation end
    Study

    n: not reported in source

    Comparator
    classical long agonist ART protocol
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Serum estradiol at end of stimulation
    929 ng/ml
    ultra-long group
    Serum estradiol at end of stimulation
    1971 ng/ml
    control group

    Source sentences

    Summary
    and a higher serum estradiol concentration (ng/ml) at the end of ovarian stimulation on the day of ovulation triggering or cycle cancellation (mean1971 (SD ± 1495) vs 929 (± 548); P = 0.0326)
    2 context sentences
    Summary · context
    Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?
    Summary · context
    the control group underwent ART stimulation in a classical long agonist protocol using preparation with oral contraceptives, the ultra-long group first underwent at least 3 months downregulation followed by a long agonist protocol for ART stimulation.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  5. 05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In operated endometriosis patients, cumulative fetal-heartbeat pregnancy rates did not differ significantly between ultra-long triptorelin and classical protocols.

    In plain wordsIn operated endometriosis patients, cumulative fetal-heartbeat pregnancy rates did not differ significantly between ultra-long triptorelin and classical protocols.

    Outcome
    No significant changeCumulative fetal-heartbeat pregnancy rate
    Study

    n = 40

    Comparator
    classical long agonist ART protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Cumulative CPHB rate
    40%
    control group
    Cumulative CPHB rate
    30%
    ultra-long group

    Source sentences

    Summary
    Cumulative (fresh + associated frozen) CPHB rates were also similar in the control versus ultra-long group (8/20, 40% vs 6/20, 30%, P = 0.7411; RR = 1.33, 95% CI 0.57-3.19).
    2 context sentences
    Summary · context
    Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?
    Summary · context
    the control group underwent ART stimulation in a classical long agonist protocol using preparation with oral contraceptives, the ultra-long group first underwent at least 3 months downregulation followed by a long agonist protocol for ART stimulation.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT02400801

Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients

Universitaire Ziekenhuizen KU Leuvenn = 166Jun 2013 to 26 Jan 2018

Endometriosis · Infertility

Trial pageClinicalTrials.govUpdated 10 Jul 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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