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Study · Animal study (in vivo) · rat · 2021

10 results

Effects of pramlintide on energy intake and food preference in rats given a choice diet.

Kern KA, DiBrog AM, Przybysz JT, Mietlicki-Baase EG

Physiology & behavior30 Jul 2021Cited by 6 (Europe PMC)

PMID34332974 (opens in a new tab)DOI10.1016/j.physbeh.2021.113541 (opens in a new tab)PepBankPUB-34332974
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats offered a choice diet, systemic pramlintide reduced high-fat diet intake at 3 hours after injection.

    In plain wordsIn rats, systemic pramlintide reduced high-fat food intake at 3 hours after injection.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseSystemic high-fat diet intake at 3 hours
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic pramlintide injection in rats reduced HFD intake at 3h post-injection, with no effects at other times and no significant effects on chow intake, body weight, or percent preference for HFD.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats offered a choice diet, systemic pramlintide did not affect high-fat diet intake at other times.

    In plain wordsIn rats, systemic pramlintide did not affect high-fat food intake at other times.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeSystemic high-fat diet intake at other times
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic pramlintide injection in rats reduced HFD intake at 3h post-injection, with no effects at other times and no significant effects on chow intake, body weight, or percent preference for HFD.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats offered a choice diet, systemic pramlintide did not significantly affect chow intake.

    In plain wordsIn rats, systemic pramlintide did not significantly affect chow intake.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeSystemic chow intake
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic pramlintide injection in rats reduced HFD intake at 3h post-injection, with no effects at other times and no significant effects on chow intake, body weight, or percent preference for HFD.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats offered a choice diet, systemic pramlintide did not significantly affect body weight.

    In plain wordsIn rats, systemic pramlintide did not significantly affect body weight.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeSystemic body weight
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic pramlintide injection in rats reduced HFD intake at 3h post-injection, with no effects at other times and no significant effects on chow intake, body weight, or percent preference for HFD.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats offered a choice diet, systemic pramlintide did not significantly affect preference for high-fat diet.

    In plain wordsIn rats, systemic pramlintide did not significantly affect high-fat food preference.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeSystemic high-fat diet preference
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic pramlintide injection in rats reduced HFD intake at 3h post-injection, with no effects at other times and no significant effects on chow intake, body weight, or percent preference for HFD.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular pramlintide reduced high-fat diet intake throughout 24 hours after injection.

    In plain wordsIn rats, pramlintide injected into a brain ventricle reduced high-fat food intake throughout 24 hours.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseCentral high-fat diet intake
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular pramlintide significantly reduced HFD intake throughout the 24h post-injection, with some suppressive effects on chow intake, and also decreased 24h body weight change.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular pramlintide had some suppressive effects on chow intake.

    In plain wordsIn rats, pramlintide injected into a brain ventricle had some suppressive effects on chow intake.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseCentral chow intake
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular pramlintide significantly reduced HFD intake throughout the 24h post-injection, with some suppressive effects on chow intake, and also decreased 24h body weight change.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular pramlintide decreased body weight change over 24 hours.

    In plain wordsIn rats, pramlintide injected into a brain ventricle decreased body weight change over 24 hours.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseCentral body weight change
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular pramlintide significantly reduced HFD intake throughout the 24h post-injection, with some suppressive effects on chow intake, and also decreased 24h body weight change.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular pramlintide did not significantly change the proportion of calories from high-fat diet.

    In plain wordsIn rats, pramlintide injected into a brain ventricle did not significantly change the calorie proportion from high-fat food.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeCentral high-fat calorie proportion
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Again, no significant changes were observed in the proportion of calories obtained from HFD.
    2 context sentences
    Summary · context
    Intracerebroventricular pramlintide significantly reduced HFD intake throughout the 24h post-injection, with some suppressive effects on chow intake, and also decreased 24h body weight change.
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).
  10. 10AnimalAnimal study (in vivo)Safety outcome

    In rats, intracerebroventricular pramlintide doses used in feeding experiments did not induce pica.

    In plain wordsIn rats, pramlintide injected into a brain ventricle did not induce pica.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changePica
    Study

    ratn: not reported in source

    Rats offered chow and high-fat diet
    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The same intracerebroventricular doses of pramlintide did not induce pica, suggesting that pramlintide-mediated reductions in feeding are not due to nausea/malaise.
    1 context sentence
    Summary · context
    Here, we investigate the effects of pramlintide on food intake and body weight in rats given a choice of chow and high fat diet (HFD).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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