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Study · Animal study (in vivo) · rhinoceros unicornis · 2021

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Case Report: Ovulation Induction in Greater One-Horned Rhinoceros (Rhinoceros unicornis).

Hermes R, Balfanz F, Haderthauer S, Dungl E, Hildebrandt TB, Schwarzenberger F

Frontiers in veterinary science30 Jun 2021Cited by 1 (Europe PMC)

PMID34277752 (opens in a new tab)PMCIDPMC8279775 (opens in a new tab)DOI10.3389/fvets.2021.657284 (opens in a new tab)PepBankPUB-34277752
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Summary

Despite a profound knowledge on reproduction biology in greater one-horned (GOH) rhinoceros, many individuals cope with sub or infertility or an-ovulatory estrous. At the same time, early and regular captive breeding is of high importance in female GOH rhinoceros due to their high prevalence to develop genital tract tumors with consequent cessation of reproduction. Thus, mature, an-ovulatory GOH rhinoceros represent a challenge for captive breeding programs and warrant for means of reliable ovulation induction. Here, we used hCG and GnRH analog histrelin to induce ovulation in an-ovulatory GOH rhinoceros. Upon ultrasound diagnosis of a preovulatory follicle hCG or GnRH were injected to induce ovulation (n = 11). As a result, 75% of the hCG (n = 6/8) and 33% of GnRH (n = 1/3) inductions resulted in ovulation. Ovulation occurred when fecal estrogen concentration increased before and pregnane concentration after induction. Thirty-six percent of all treatments (n = 4/11) failed to induce ovulation. When ovulation induction by hCG/GnRH injection failed, estrogen and pregnane concentrations were significantly lower compared to ovulatory estrous (P < 0.001). Our results suggest that hCG and GnRH analog facilitate an easily applicable treatment to induce ovulation in females with behavioral but at times an-ovulatory estrous. Frequent use of hCG as an ovulation inducer might help to achieve pregnancies in genetically important but an-ovulatory GOH rhinoceroses.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In an-ovulatory greater one-horned rhinoceros, histrelin induced ovulation in 33% of inductions (1/3).

    In plain wordsIn an-ovulatory greater one-horned rhinoceros, histrelin induced ovulation in 33% of inductions (1/3).

    Peptide
    Histrelin
    Outcome
    Not applicableOvulation induction
    Study

    Rhinoceros unicornisn: not reported in source

    An-ovulatory female greater one-horned rhinoceros
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · injectionAs given in this study (Rhinoceros unicornis).

    Measurements

    Ovulation induction
    33%
    GnRH histrelin
    Successful inductions
    1 inductions
    GnRH histrelin

    Source sentences

    Summary
    As a result, 75% of the hCG (n = 6/8) and 33% of GnRH (n = 1/3) inductions resulted in ovulation.
    2 context sentences
    Summary · context
    Here, we used hCG and GnRH analog histrelin to induce ovulation in an-ovulatory GOH rhinoceros.
    Summary · context
    Upon ultrasound diagnosis of a preovulatory follicle hCG or GnRH were injected to induce ovulation (n = 11).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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