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Study · In vitro (cells) · mouse and rat · 2021

11 results

Mutual Interactions Between GnRH and Kisspeptin in GnRH- and Kiss-1-Expressing Immortalized Hypothalamic Cell Models.

Kanasaki H, Tumurbaatar T, Tumurgan Z, Oride A, Okada H, Kyo S

Reproductive sciences (Thousand Oaks, Calif.)15 Jul 2021Cited by 4 (Europe PMC)

PMID34268716 (opens in a new tab)DOI10.1007/s43032-021-00695-z (opens in a new tab)PepBankPUB-34268716
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV hypothalamic cells, KP10 and GnRH stimulation significantly increased Kiss-1 mRNA expression.

    In plain wordsIn mouse brain cells, KP10 raised the activity of the gene for kisspeptin itself.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiss-1 mRNA in mHypoA-50 cells
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Kiss-1 mRNA expression was significantly increased in mHypoA-50 AVPV cells by KP10 and GnRH stimulation.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  2. 02LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV cells, KP10 and GnRH stimulation increased kisspeptin protein expression.

    In plain wordsIn mouse brain cells, KP10 increased levels of kisspeptin protein.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin protein in mHypoA-50 cells
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin protein expression was also increased by KP10 and GnRH stimulation in these cells.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  3. 03LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV cells, GnRH expression did not change with KP10 and GnRH stimulation.

    In plain wordsIn mouse brain cells, KP10 did not change GnRH expression.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGnRH expression in mHypoA-50 cells
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, GnRH expression was unchanged in mHypoA-50 AVPV cells by KP10 and GnRH stimulation.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  4. 04LabIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, KP10 and GnRH stimulation significantly increased kisspeptin expression at the mRNA and protein levels.

    In plain wordsIn mouse brain cells, KP10 increased kisspeptin mRNA and protein.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin mRNA and protein in mHypoA-55 cells
    Study

    mousen: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mHypoA-55 ARC cells, kisspeptin expression was also significantly increased at the mRNA and protein levels by KP10 and GnRH stimulation
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  5. 05LabIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, KP10 and GnRH stimulation upregulated GnRH expression.

    In plain wordsIn mouse brain cells, KP10 increased GnRH expression.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH expression in mHypoA-55 cells
    Study

    mousen: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mHypoA-55 ARC cells, kisspeptin expression was also significantly increased at the mRNA and protein levels by KP10 and GnRH stimulation; however, GnRH expression was also upregulated by KP10 and GnRH stimulation in these cells.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  6. 06LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV cells, KP10 increased Kiss-1 gene expression.

    In plain wordsIn mouse brain cells, KP10 increased the activity of the kisspeptin gene.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiss-1 gene expression after KP10 alone
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and estradiol (E2) both increased Kiss-1 gene expression in mHypoA-50 AVPV cells
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  7. 07LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV cells, combined KP10 and estradiol stimulation did not potentiate the individual effects of each on Kiss-1 gene expression.

    In plain wordsIn mouse brain cells, KP10 together with estradiol did not increase kisspeptin gene activity more than each alone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKiss-1 expression after KP10 plus E2 versus each alone
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Comparator
    KP10 alone and E2 alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and estradiol (E2) both increased Kiss-1 gene expression in mHypoA-50 AVPV cells, but combined stimulation with KP10 and E2 did not potentiate their individual effects on Kiss-1 gene expression.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  8. 08LabIn vitro (cells)Mechanism

    In mHypoA-50 AVPV cells, KP10 and GnRH significantly increased c-Fos protein expression.

    In plain wordsIn mouse brain cells, KP10 increased c-Fos, a marker of cell activation.

    Peptide
    Kisspeptin-10
    Outcome
    Increasec-Fos protein in mHypoA-50 cells
    Study

    mousen: not reported in source

    mHypoA-50 AVPV hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and GnRH significantly increased c-Fos protein expression in the mHypoA-50 AVPV and mHypoA-55 ARC cell lines.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  9. 09LabIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, KP10 and GnRH significantly increased c-Fos protein expression.

    In plain wordsIn mouse brain cells, KP10 increased c-Fos, a marker of cell activation.

    Peptide
    Kisspeptin-10
    Outcome
    Increasec-Fos protein in mHypoA-55 cells
    Study

    mousen: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and GnRH significantly increased c-Fos protein expression in the mHypoA-50 AVPV and mHypoA-55 ARC cell lines.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…
  10. 10LabIn vitro (cells)Mechanism

    In primary cultures of fetal rat neuronal cells, KP10 significantly increased Kiss-1 gene expression.

    In plain wordsIn rat brain cells grown in the lab, KP10 increased the activity of the kisspeptin gene.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiss-1 gene expression in primary fetal rat neuronal cells
    Study

    ratn: not reported in source

    Primary cultures of fetal rat brain cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In primary cultures of fetal rat neuronal cells, KP10 significantly increased Kiss-1 gene expression
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 11LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, estradiol inhibited the KP10-induced increase of Kiss-1 gene expression.

    In plain wordsIn mouse brain cells, estradiol blocked the rise in kisspeptin gene activity caused by KP10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKP10-induced Kiss-1 expression with E2
    Study

    mousen: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Comparator
    KP10 alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    On the other hand, E2 did not increase Kiss-1 gene expression in mHypoA-55 ARC cells, and the KP10-induced increase of Kiss-1 gene expression was inhibited in the presence of E2 in these cells.
    1 context sentence
    Summary · context
    Recently established mHypoA-50 and mHypoA-55 cells are immortalized hypothalamic neuronal cell models that originated from the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) regions of the mouse hypothalamus, respectively. mHypoA-50 or mHypoA-55 cells were stimulated with kis…

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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