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Study · In vitro (cells) · 2021

4 results

Effect of anti-Müllerian hormone in hypothalamic Kiss-1- and GnRH-producing cell models.

Oride A, Kanasaki H, Tumurbaatar T, Tumurgan Z, Okada H, Kyo S

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology8 Jul 2021Cited by 3 (Europe PMC)

PMID34236272 (opens in a new tab)DOI10.1080/09513590.2021.1950134 (opens in a new tab)PepBankPUB-34236272
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, KP10 increased Kiss-1 gene expression.

    In plain wordsIn brain cells in the lab, KP10 increased the activity of the kisspeptin gene.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiss-1 gene expression after KP10
    Study

    n: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 (KP10) increased Kiss-1 gene expression in mHypoA-55 ARC cells

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02LabEndogenous levelIn vitro (cells)Mechanism

    In mHypoA-50 AVPV and mHypoA-55 ARC cells, exogenous anti-Mullerian hormone did not change Kiss-1 gene expression.

    In plain wordsIn brain cells in the lab, anti-Mullerian hormone did not change the activity of the gene for the body's own kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKiss-1 gene expression after AMH in mHypoA-50 and mHypoA-55 cells
    Study

    n: not reported in source

    mHypoA-50 AVPV and mHypoA-55 ARC hypothalamic cell lines
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Exogenous AMH failed to alter the expression levels of the Kiss-1 gene in both cell models

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 03LabEndogenous levelIn vitro (cells)Mechanism

    In primary cultures of fetal rat brain cells, 100 pM anti-Mullerian hormone did not change Kiss-1 mRNA expression.

    In plain wordsIn rat brain cells grown in the lab, anti-Mullerian hormone did not change the activity of the gene for the body's own kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKiss-1 mRNA after AMH in primary fetal rat brain cells
    Study

    ratn: not reported in source

    Primary cultures of fetal rat brain cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Similar to the phenomenon observed in the hypothalamic cell lines, 100 pM AMH significantly increased GnRH, but not Kiss-1, mRNA expression in primary cultures of fetal rat brain cells

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In mHypoA-55 ARC cells, anti-Mullerian hormone blocked the KP10-induced increase of Kiss-1 gene expression.

    In plain wordsIn brain cells in the lab, anti-Mullerian hormone blocked the rise in kisspeptin gene activity caused by KP10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKP10-induced Kiss-1 expression with AMH
    Study

    n: not reported in source

    mHypoA-55 ARC hypothalamic cells
    Comparator
    KP10 alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Kisspeptin-10 (KP10) increased Kiss-1 gene expression in mHypoA-55 ARC cells but this was blocked by AMH.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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