Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade.

Singh A, Lal B, Parkash J, Millar RP

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology28 Jun 2021Cited by 7 (Europe PMC)

PMID34197962DOI10.1016/j.cbpb.2021.110642PepBankPUB-34197962

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In gonadally quiescent Asian catfish, in vivo KP-10 caused precocious onset of gametogenesis and its rapid progression compared with control gonads.
In plain wordsIn catfish, kisspeptin‑10 made egg and sperm development start early and progress faster than in untreated fish.
Peptide
Kisspeptin-10
Outcome
IncreaseOnset and progression of gametogenesis
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadally quiescent Asian catfish
Comparator
Control gonads
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The in vivo KP-10 treatment caused precocious onset of gametogenesis and its rapid progression, as was evident from the appearance of advanced stages of ovarian follicles in ovary, and advanced germ cells (spermatocytes/ spermatids) in the testis of the treated Clarias batrachus in comparison to the control gonads.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796201
02AnimalAnimal study (in vivo)Efficacy outcome
In Asian catfish, KP-10 elevated steroid levels in the gonads in vivo.
In plain wordsIn catfish, kisspeptin‑10 raised sex steroid levels in the gonads.
Peptide
Kisspeptin-10
Outcome
IncreaseGonadal steroid levels in vivo
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadally quiescent Asian catfish
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
It also elevated the steroid levels in gonads of the catfish in vivo and in vitro conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796202
03AnimalAnimal study (in vivo)Mechanism
In Asian catfish, KP-10 increased the expression of the steroidogenic enzyme 3β-HSD.
In plain wordsIn catfish, kisspeptin‑10 increased levels of an enzyme that makes sex steroids.
Peptide
Kisspeptin-10
Outcome
Increase3β-HSD expression
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadally quiescent Asian catfish
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Simultaneously, it increased the expressions of key steroidogenic enzymes like 3β-HSD, 17β-HSD, and StAR protein, responsible for transfer of cholesterol from outer to inner membrane of the mitochondria of steroidogenic cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796204
04AnimalAnimal study (in vivo)Mechanism
In Asian catfish, KP-10 increased the expression of the steroidogenic enzyme 17β-HSD.
In plain wordsIn catfish, kisspeptin‑10 increased levels of a second enzyme that makes sex steroids.
Peptide
Kisspeptin-10
Outcome
Increase17β-HSD expression
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadally quiescent Asian catfish
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Simultaneously, it increased the expressions of key steroidogenic enzymes like 3β-HSD, 17β-HSD, and StAR protein, responsible for transfer of cholesterol from outer to inner membrane of the mitochondria of steroidogenic cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796205
05AnimalAnimal study (in vivo)Mechanism
In Asian catfish, KP-10 increased the expression of StAR protein.
In plain wordsIn catfish, kisspeptin‑10 increased levels of StAR protein, which moves cholesterol for steroid production.
Peptide
Kisspeptin-10
Outcome
IncreaseStAR protein expression
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadally quiescent Asian catfish
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Simultaneously, it increased the expressions of key steroidogenic enzymes like 3β-HSD, 17β-HSD, and StAR protein, responsible for transfer of cholesterol from outer to inner membrane of the mitochondria of steroidogenic cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796206
06LabEx vivo tissueEfficacy outcome
In Asian catfish gonad explants, KP-10 elevated steroid levels in vitro.
In plain wordsIn catfish gonad tissue in the lab, kisspeptin‑10 raised sex steroid levels.
Peptide
Kisspeptin-10
Outcome
IncreaseGonadal steroid levels in vitro
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadal explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
It also elevated the steroid levels in gonads of the catfish in vivo and in vitro conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796203
07LabEx vivo tissueMechanism
In catfish ovarian explants, KP-10 augmented 3β-HSD activity.
In plain wordsIn catfish ovary tissue in the lab, kisspeptin‑10 increased the activity of an enzyme that makes sex steroids.
Peptide
Kisspeptin-10
Outcome
Increase3β-HSD activity in ovarian explants
Study
Asian catfish (Clarias batrachus)n: not reported in source
ovarian explants
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concurrently, it augmented the activities of 3β-HSD and 17β-HSD in the ovarian explants.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796207
08LabEx vivo tissueMechanism
In catfish ovarian explants, KP-10 augmented 17β-HSD activity.
In plain wordsIn catfish ovary tissue in the lab, kisspeptin‑10 increased the activity of a second steroid-making enzyme.
Peptide
Kisspeptin-10
Outcome
Increase17β-HSD activity in ovarian explants
Study
Asian catfish (Clarias batrachus)n: not reported in source
ovarian explants
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concurrently, it augmented the activities of 3β-HSD and 17β-HSD in the ovarian explants.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796208
09LabEx vivo tissueMechanism
In catfish gonadal explants, KP-10 up-regulated pERK1/2 expression.
In plain wordsIn catfish gonad tissue in the lab, kisspeptin‑10 raised the level of an active signalling protein, pERK1/2.
Peptide
Kisspeptin-10
Outcome
IncreasepERK1/2 expression in gonadal explants
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadal explants
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The expressions of MAPK component (pERK1/2 and ERK1/2) were also up-regulated by KP-10 in gonadal explants.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796209
10LabEx vivo tissueMechanism
In catfish gonadal explants, KP-10 up-regulated ERK1/2 expression.
In plain wordsIn catfish gonad tissue in the lab, kisspeptin‑10 raised the level of the signalling protein ERK1/2.
Peptide
Kisspeptin-10
Outcome
IncreaseERK1/2 expression in gonadal explants
Study
Asian catfish (Clarias batrachus)n: not reported in source
gonadal explants
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The expressions of MAPK component (pERK1/2 and ERK1/2) were also up-regulated by KP-10 in gonadal explants.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches.
Report a problemFND-3419796210

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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