In rats with L-NAME-induced retinal ischemia, retrobulbar BPC‑157 given at 20 min or 48 h after L-NAME made the L-NAME findings disappear, leaving only discrete vessel irregularity and mild optic disc atrophy, then a normal eye background.
In plain wordsIn rats with induced eye ischemia, BPC‑157 given early or late made the eye damage signs disappear.
- Peptide
- BPC-157
- Outcome
- DecreaseFundoscopy findings after L-NAME (vessel caliber, optic disc atrophy)
- Study
ratn: not reported in source
Retrobulbar L-NAME-induced retinal ischemia- Comparator
- L-NAME without BPC 157
- Outcome group
- Neuroprotection · Eye
- Studied dose
- 10 μg; 10 ng/kg (1 μg; 1 ng/0.1 ml saline per eye) · retrobulbarAs given in this study (rat).
Source sentences
When BPC 157 (10 μg; 10 ng/kg, as retrobulbar application, 1 μg; 1 ng/0.1 ml saline/each eye) is given at either 20 min after L-NAME or, lately, at 48 h after L-NAME, the regular retrobulbar L-NAME injection findings disappear.
2 context sentences(design, population, supporting numbers)
Instead, fundoscopy demonstrated only discrete generalized vessel caliber irregularity with mild atrophy of the optic disc, and then, quite rapidly, normal eye background and choroidal blood vessels, which remain in all of the subsequent periods.
A rat retinal ischemia study was conducted throughout 4 weeks, including fundoscopy, behavior presentation, tonometry, and histology assessment.