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Study · Animal study (in vivo) · rat · 2020

2 results

Pentadecapeptide BPC 157 shortens duration of tetracaine- and oxybuprocaine-induced corneal anesthesia in rats.

Mirković I, Kralj T, Lozić M, Stambolija V, Kovačević J, Vrdoljak L, Zlatar M, Milanović K, Drmić D, Predović J, Masnec S, Jurjević M and 4 more

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Bušić M, Seiwerth S, Kokot A, Sikirić P

Acta clinica Croatica1 Sept 2020Cited by 10 (Europe PMC)

PMID34177048 (opens in a new tab)PMCIDPMC8212645 (opens in a new tab)DOI10.20471/acc.2020.59.03.02 (opens in a new tab)PepBankPUB-34177048
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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with tetracaine- or oxybuprocaine-induced corneal anesthesia, BPC‑157 had a full counteracting effect.

    In plain wordsIn rats given eye anesthetics, BPC‑157 fully counteracted the anesthetic effect.

    Peptide
    BPC-157
    Outcome
    DecreaseCounteraction of topical anesthetic-induced corneal effects
    Study

    ratn: not reported in source

    Rat corneal anesthesia induced by tetracaine or oxybuprocaine
    Outcome group
    Ocular surface · Eye
    Studied dose
    0.4 µg/eye · eye dropsAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 administration had a full counteracting effect.
    1 context sentence
    Summary · context
    We focused on the relationship of 0.5% tetracaine- and 0.4% oxybuprocaine-induced corneal anesthesia in rats, and pentadecapeptide BPC 157 (0.4 µg/eye), along with nitric oxide synthase (NOS) inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) (0.1 mg/eye) and/or NOS substrate L-arginine (2 mg…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with topical anesthetic-induced corneal effects, recovery with BPC‑157 also occurred in the presence of NOS blockade and NOS substrate application.

    In plain wordsIn rats given eye anesthetics, recovery with BPC‑157 also occurred when nitric oxide pathway drugs were given.

    Peptide
    BPC-157
    Outcome
    DecreaseCounteraction with NOS blockade or NOS substrate
    Study

    ratn: not reported in source

    Rat corneal anesthesia induced by tetracaine or oxybuprocaine
    Outcome group
    Ocular surface · Eye
    Studied dose
    0.4 µg/eye · eye dropsAs given in this study (rat).

    Source sentences

    Summary
    Recovery also occurred in the presence of NOS blockade and NOS substrate application.
    1 context sentence
    Summary · context
    We focused on the relationship of 0.5% tetracaine- and 0.4% oxybuprocaine-induced corneal anesthesia in rats, and pentadecapeptide BPC 157 (0.4 µg/eye), along with nitric oxide synthase (NOS) inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) (0.1 mg/eye) and/or NOS substrate L-arginine (2 mg…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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