Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis.

Kalnitsky AS, Zharikov AY, Mazko ON, Makarova OG, Bobrov IP, Azarova OV

Bulletin of experimental biology and medicine1 May 2021Cited by 1 (Europe PMC)

PMID34173110DOI10.1007/s10517-021-05198-0PepBankPUB-34173110

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine decreased TBA-reactive products 1.4-fold.
In plain wordsIn rats with urate kidney stones, carnosine reduced TBA-reactive products.
Peptide
L-carnosine
Outcome
DecreaseTBA-reactive products
Study
ratn: not reported in source
Urate nephrolithiasis
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Measurements
TBA-reactive products reduction
1.4 fold
carnosine-treated rats
Source sentences
Summary
In rats treated with carnosine, the concentration of TBA-reactive products decreased by 1.4 times, the total antioxidant activity increased by 1.4 times, and catalase activity increased by 1.3 times.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine increased total antioxidant activity 1.4-fold.
In plain wordsIn rats with urate kidney stones, carnosine increased total antioxidant activity.
Peptide
L-carnosine
Outcome
IncreaseTotal antioxidant activity
Study
ratn: not reported in source
Urate nephrolithiasis
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Measurements
Total antioxidant activity increase
1.4 fold
carnosine-treated rats
Source sentences
Summary
In rats treated with carnosine, the concentration of TBA-reactive products decreased by 1.4 times, the total antioxidant activity increased by 1.4 times, and catalase activity increased by 1.3 times.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine increased catalase activity 1.3-fold.
In plain wordsIn rats with urate kidney stones, carnosine increased catalase activity.
Peptide
L-carnosine
Outcome
IncreaseCatalase activity
Study
ratn: not reported in source
Urate nephrolithiasis
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Measurements
Catalase activity increase
1.3 fold
carnosine-treated rats
Source sentences
Summary
In rats treated with carnosine, the concentration of TBA-reactive products decreased by 1.4 times, the total antioxidant activity increased by 1.4 times, and catalase activity increased by 1.3 times.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine halved lactate dehydrogenate levels compared with control.
In plain wordsIn rats with urate kidney stones, carnosine lowered lactate dehydrogenate levels compared with control.
Peptide
L-carnosine
Outcome
DecreaseLactate dehydrogenate level
Study
ratn: not reported in source
Urate nephrolithiasis
Comparator
Control
Outcome group
Kidney function · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Measurements
Lactate dehydrogenate reduction
2 fold
versus control
Source sentences
Summary
By the end of the experiment, the lactate dehydrogenate level in experimental rats was 2-fold lower than in the control, and the number of urate deposits decreased by 1.6 times with a concomitant alleviation of the inflammatory processes.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine decreased urate deposits 1.6-fold.
In plain wordsIn rats with urate kidney stones, carnosine reduced urate deposits.
Peptide
L-carnosine
Outcome
DecreaseUrate deposits
Study
ratn: not reported in source
Urate nephrolithiasis
Outcome group
Kidney function · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Measurements
Urate deposits reduction
1.6 fold
carnosine-treated rats
Source sentences
Summary
By the end of the experiment, the lactate dehydrogenate level in experimental rats was 2-fold lower than in the control, and the number of urate deposits decreased by 1.6 times with a concomitant alleviation of the inflammatory processes.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with urate nephrolithiasis, carnosine alleviated inflammatory processes.
In plain wordsIn rats with urate kidney stones, carnosine reduced inflammation.
Peptide
L-carnosine
Outcome
DecreaseInflammatory processes
Study
ratn: not reported in source
Urate nephrolithiasis
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
15 mg/kg · intragastricAs given in this study (rat).
Source sentences
Summary
By the end of the experiment, the lactate dehydrogenate level in experimental rats was 2-fold lower than in the control, and the number of urate deposits decreased by 1.6 times with a concomitant alleviation of the inflammatory processes.
2 context sentences(design, population, supporting numbers)
Summary · context
Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids.
Summary · context
Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
Report a problemFND-3417311006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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