Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells.

Yoon HJ, Oh YL, Ko EJ, Kang A, Eo WK, Kim KH, Lee JY, Kim A, Chun S, Kim H, Ock MS, Cha HJ

Genes & genomics25 Jun 2021Cited by 6 (Europe PMC)

PMID34170491DOI10.1007/s13258-021-01127-7PepBankPUB-34170491

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In SKOV3 ovarian cancer cells, Tβ4 significantly increased cell migration compared with untreated control.
In plain wordsIn ovarian cancer cells, Tβ4 increased cell migration compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSKOV3 cell migration
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Cell migration and invasion were significantly increased in Tβ4 peptide-treated SKOV3 cells compared with untreated control.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
Report a problemFND-3417049101
02LabIn vitro (cells)Efficacy outcome
In SKOV3 ovarian cancer cells, Tβ4 significantly increased cell invasion compared with untreated control.
In plain wordsIn ovarian cancer cells, Tβ4 increased cell invasion compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSKOV3 cell invasion
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Cell migration and invasion were significantly increased in Tβ4 peptide-treated SKOV3 cells compared with untreated control.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
Report a problemFND-3417049102

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In SKOV3 cells, three Tβ4-derived fragment peptides, including those without an actin binding site, significantly stimulated migration.
In plain wordsIn ovarian cancer cells, three fragments of Tβ4 increased cell migration compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSKOV3 cell migration with Tβ4-derived fragment peptides
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Tumor growth · Cancer
Source sentences
Summary
All three Tβ4-derived fragment peptides including those without an actin binding site significantly stimulated migration and invasion of SKOV3 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3417049103
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In SKOV3 cells, three Tβ4-derived fragment peptides, including those without an actin binding site, significantly stimulated invasion.
In plain wordsIn ovarian cancer cells, three fragments of Tβ4 increased cell invasion compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSKOV3 cell invasion with Tβ4-derived fragment peptides
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Tumor growth · Cancer
Source sentences
Summary
All three Tβ4-derived fragment peptides including those without an actin binding site significantly stimulated migration and invasion of SKOV3 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3417049104
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In SKOV3 cells, Tβ4 and its derived peptide significantly stimulated cell proliferation.
In plain wordsIn ovarian cancer cells, Tβ4 and a derived peptide each increased cell proliferation compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSKOV3 cell proliferation with Tβ4 and derived peptides
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 and its derived peptide significantly stimulated SKOV3 cell proliferation and up-regulated the expression of RACK-1 protein.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3417049105
06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SKOV3 cells, Tβ4 and its derived peptide up-regulated the expression of RACK-1 protein.
In plain wordsIn ovarian cancer cells, Tβ4 and a derived peptide each raised the level of the RACK-1 protein compared with untreated cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseRACK-1 protein expression with Tβ4 and derived peptides
Study
humann: not reported in source
SKOV3 ovarian cancer cells
Comparator
Untreated control
Outcome group
Receptor activity and mechanism · Cancer
Source sentences
Summary
Tβ4 and its derived peptide significantly stimulated SKOV3 cell proliferation and up-regulated the expression of RACK-1 protein.
1 context sentence(design, population, supporting numbers)
Summary · context
To analyze the effects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3417049106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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